肝癌介入治疗后发生肝脓肿的危险因素分析  

Study on the Risk Factors of Liver Abscess after Interventional Therapy

作　　者：周波[1] 王建华[1] 颜志平[1] 

机构地区：[1]复旦大学附属中山医院介入放射科,上海200032

出　　处：《中国临床医学》2010年第1期51-53,共3页Chinese Journal of Clinical Medicine

摘　　要：目的:分析肝癌介入治疗后发生脓肿的可能危险因素,为临床治疗和预防介入术后肝脓肿提供依据。方法:2004年9月—2008年3月肝癌介入治疗后发生肝脓肿15例,非肿瘤肝脓肿4例,再随机抽取同期17例肝癌介入治疗后无肝脓肿患者作为对照组。收集各研究对象的血常规,肝肾功能,凝血功能,肿瘤标记物和影像学及临床表现等资料,分析介入后发生肝脓肿的高危因素。结果:肝癌肝脓肿患者在性别构成(P=0.005)、胆道损伤(P=0.034)、营养状况(血红蛋白水平P=0.001;血清白蛋白水平P=0.029)、原发性肿瘤构成比(P=0.013)方面和对照组有统计学差异。结论:女性患者和转移性肿瘤患者发生介入后肝脓肿的机会更高,减少胆道损伤和改善患者营养状况有助于减少介入后肝脓肿发生。Objective：To find out the risk factors of liver abscess after interventional therapy and develop effective way to improve clinical treatment and precaution of restenosis. Methods： The data from a registry of 15 patients who underwent interven- tional therapy and had liver abscess later in our department between Sept. 2004 and Mar. 2008 were retrospectively reviewed. Four cases of liver abscess without cancer and 17 cases of tumor patients who underwent interventional therapy were reviewed in contrast. Results： Among all the factors, female patients and metastasis liver tumor patients had high incidence of liver ab scess after interventional therapy（P = 0. 005;P = 0. 013）. The damage of biliary tract and dystrophia had correlation about liver abscess after interventional therapy（P = 0. 034;P〈0. 001 ）. Conclusions： Female patients and metastasis liver tumor patients were more likely to have liver abscess after interventional therapy. Decreasing the damage of biliary tract and improve the nutrition situation maybe have effect on reducing incidence of liver abscess after interventional therapy.

关 键 词：肝脓肿 介入治疗 危险因素 肝动脉化疗栓塞术 经皮穿肝胆道引流术 

分 类 号：R733[医药卫生—肿瘤] R730.52[医药卫生—临床医学]