生长因子及其受体作为乳腺癌转移与预后血清标志物的临床价值  

Clinical Value of Growth Factors and Their Receptors for the Metastasis and Prognosis of Breast Cancer

作　　者：徐媛媛(综述)[1] 冯玉梅(审校)[1] 

机构地区：[1]天津医科大学附属肿瘤医院,肿瘤研究所生物化学及分子生物学室,乳腺癌防治教育重点实验室,天津市300060

出　　处：《中国肿瘤临床》2010年第4期234-237,共4页Chinese Journal of Clinical Oncology

基　　金：国家自然科学基金(编号:30872518);天津市应用基础研究项目(编号:06YFJMJC12900);教育部长江学者和创新团队发展计划基金资助(编号:IRT0743)~~

摘　　要：生长因子通过与细胞膜相应受体的特异性高亲和力结合,增强肿瘤细胞生长与迁移能力,促进肿瘤组织中血管生成,诱导肿瘤组织周围微环境改变,调节患者免疫应答功能,在肿瘤发生、发展中起重要作用。表皮生长因子及其受体、转化生长因子及其受体、胰岛素样生长因子家族、血管生成因子等是潜在的乳腺癌转移预后的血清标志物,有望用于判断转移状态、监测治疗效果和预测患者预后。联合检测血清中在乳腺癌进展和转移过程中有协同作用或相互影响的生长因子和生长因子受体的水平,有望提高判断乳腺癌转移和预测患者预后准确性,并将为乳腺癌血清标志物研究和应用奠定基础。Through its high affinity with membrane receptors, growth factors promote tumor growth, metastasis and an- giogenesis, induce the change of tumor microenvironment and regulate immune response. It has been demonstrated that the serum protein levels of epidermal growth factor and its receptor, transforming growth factors and their receptors, insu- lin-like growth factors, and angiogenesis factors may have predictive value for metastasis and prognosis of breast cancer. Detecting serum levels of growth factors and their receptors which have synergistic effect or interaction with each other may be helpful for predicting the metastasis and progression of breast cancer.

关 键 词：乳腺癌 预后 生长因子 生长因子受体血清标志物 

分 类 号：R734.2[医药卫生—肿瘤] R735.2[医药卫生—临床医学]