fascin及Ki-67蛋白在膀胱癌中的表达及意义  

Expression and Significance of Fascin and Ki-67 Proteins in Bladder Carcinoma

作　　者：陈雪磊[1] 李炳勋[1] 沈海林[1] 陈启光[1] 张哲[1] 毕建斌[1] 孔垂泽[1] 

机构地区：[1]中国医科大学附属第一医院泌尿外科,沈阳110001

出　　处：《中国医科大学学报》2010年第2期135-137,共3页Journal of China Medical University

基　　金：辽宁省自然科学基金资助项目(20082094)

摘　　要：目的观察肌成束蛋白(fascin)及Ki-67蛋白在膀胱上皮癌中的表达,并探讨fascin表达与肿瘤临床病理指标及Ki-67的关系。方法用免疫组织化学方法检测在111例膀胱上皮癌标本及42例正常上皮中fascin及Ki-67蛋白的表达,统计分析其表达与膀胱癌生物学行为的关系,并分析二者的相关性。结果fascin及Ki-67蛋白在正常移行上皮中均无表达,111例膀胱上皮癌标本中fascin有94例呈阳性表达,Ki-67有92例呈阳性表达,统计分析差异显著(P<0.01)。在膀胱上皮癌标本中,fascin表达与肿瘤临床分期、肿瘤大小具有相关性(P<0.05),与年龄、性别、肿瘤病理分级无相关性(P>0.05)。fascin与Ki-67蛋白在膀胱上皮癌中的表达具有明显的正相关关系(P<0.01)。结论fascin及Ki-67蛋白在膀胱上皮癌中表达上调且和肿瘤的进展相关。二者结合起来,有助于膀胱上皮癌的早期诊断和预后评估,并有可能成为肿瘤治疗的新靶点。Objective To study the immunoreactivity of fascin and Ki-67 proteins in bladder carcinoma and the correlation between their expression and the pathological features. Methods The immunohistochemistry of fascin and Ki-67 proteins were detected in 111 cases of bladder carcinoma and 42 cases of normal bladder tissues. The correlation between their expression and the pathological features were analyzed statistically. Results There was no expression of fascin and Ki-67 in normal bladder tissues. The immunoreactivities of fascin and Ki- 67 were detected respectively in 94 and 92 of 111 bladder carcinomas. The immunoreactivity of fascin was correlated with TNM staging and the size of the tamor（P 〈 0.05 ）,and had no correlation with age, gender and pathological classification （P 〉 0.05 ）. The expression of fascin was positively correlated with the expression of Ki-67 in bladder carcinoma （P 〈 0.01 ）. Conclusion Fasicn and Ki-67 were expressed in bladder carcinoma. The combined detection of fascin and Ki-67 expression might be helpful to assess the prognosis of bladder carcinoma. Targeting the fascin and Ki-67 pathway could be a novel therapeutic strategy of bladder carcinoma.

关 键 词：膀胱癌 肌成束蛋白 KI-67 免疫组织化学 

分 类 号：R737.11[医药卫生—肿瘤]