肺炎衣原体感染与肺癌关系的Meta分析  

Meta-analysis of the Relationship between Chlamydia Pneumoniae Infection and Lung Cancer

作　　者：刘壮[1] 尹智华[1] 周宝森[1] 

机构地区：[1]中国医科大学公共卫生学院流行病学教研室,循证医学中心,沈阳110001

出　　处：《中国医科大学学报》2010年第2期138-139,143,共3页Journal of China Medical University

基　　金：辽宁省自然科学基金资助项目(20072103);辽宁省教育厅高校重点实验室项目(2008S232)

摘　　要：目的综合评价肺炎衣原体(CP)感染与肺癌之间的关系。方法检索国内外各大类型数据库,获得有关CP感染与肺癌关系的文献,采用Revman4.2软件对各类文献进行Meta分析,并计算合并OR值及其95%可信区间,倒漏斗图法定性评价发表性偏倚。结果共纳入原始文献10篇,累计病例1769例,对照1922例。经Meta分析得出慢性肺炎衣原体感染与肺癌发病合并OR值为2.17,95%可信区间为1.43～3.28。结论慢性CP感染与肺癌之间存在相关关系,CP感染可能是肺癌的危险因素之一。Objective To evaluate the relationship between Chlamydia pneumoniae （CP） infection and lung cancer. Methods Literatures that reported on the associations between CP and lung cancer were retrieved by searching international and national databases. Meta-analysis was done by RevMan 4.2 software. The pooled OR values and 95%CI were calcalated,and pubhshed bias was assessed by funnel plots. Results Totally 10 studies with 1 769 cases and 1 922 controls were enrolled. The analysis showed that the pooled OR of the association between chronic CP infection and lung cancer was 2.17 with the 95%CI of 1.43 to 3.28. Conclusion CP infection may be associated with lung cancer. CP infection may be a potential risk factor for lung cancer.

关 键 词：肺炎衣原体 慢性感染 肺癌 META分析 

分 类 号：R734.2[医药卫生—肿瘤]