胃癌患者血清补体C3a的检测及其临床意义  

The assay and clinical significiance of serum complement C3a in patients with gastric carcinoma

作　　者：张勇超[1] 庄竞[1] 

机构地区：[1]河南省肿瘤医院,郑州450008

出　　处：《中国肿瘤临床与康复》2010年第1期21-23,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨血清补体C3a的检测对胃癌诊治的临床价值。方法用酶联免疫吸附法检测胃癌、大肠癌、食管癌以及胃良性疾病患者和健康人的血清补体C3a水平。结果胃癌患者血清补体C3a水平明显高于其他各组(P<0.01)。胃良性疾病患者、大肠癌、食管癌组血清补体C3a水平与健康人比较差异无显著性(P>0.05)。胃癌患者手术后血清补体C3a水平明显下降。结论血清补体C3a检测对胃癌的辅助诊断、监测疗效、判断预后具有一定的临床应用价值,可能成为一种新的胃癌肿瘤标志物。Objective To investigate the diagnostic value of serum complement C3a in gastric cancer.Methods The levels of serum complement C3a in patients with gastric cancer,gastric benign disease,colorectal cancer,esophageal cancer and normal controls were determined by enzyme-linked immunosorbent assay.Results The levels of serum complement C3a in patients with gastric carcinoma were much higher than those in patients with gastric benign disease,colorectal cancer,esophageal cancer and normal controls（P 〈0.01）,but there was no significant difference between patients with gastric benign disease,colorectal cancer,esophageal cancer and normal controls（P 〉 0.05）.The level of serum complement C3a in patients with gastric carcinoma declined significantly one month after operation.Conclusions The detection of serum complement C3a may have value in the diagnosis,monitoring and prognosis of gastric cancer.Serum complement C3a may be used as a new tumor marker in diagnosis and therapy of gastric cancer.

关 键 词：补体C3a 胃肿瘤 肿瘤标志物 

分 类 号：R735.2[医药卫生—肿瘤] R730.43[医药卫生—临床医学]