铜绿假单胞菌注射液治疗恶性胸腔积液和心包积液的临床分析  

Treatment of 26 cases of malignant pleural effcsion and hydropericardium with pseudomonas aeruginosa injection

作　　者：朱继庆[1] 吴晓明[1] 

机构地区：[1]中国医学科学院肿瘤医院综合科,北京100021

出　　处：《中国肿瘤临床与康复》2010年第1期93-94,F0003,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的观察铜绿假单胞菌注射液治疗恶性胸腔积液和心包积液的疗效。方法共治疗恶性胸腔积液、心包积液26例。所有患者先行中心静脉导管置管进行积液引流,引流后注入铜绿假单胞菌注射液2～5ml和地塞米松5mg,2%利多卡因10ml,夹闭引流管48h,再开放引流管,根据引流情况连续注药2～3次。结果治疗恶性胸腔积液20例,有效18例(90.0%);恶性心包积液10例均有效,不良反应为胸痛、气短、发热。结论铜绿假单胞菌注射液应用于恶性胸腔积液、心包积液的治疗,疗效较满意。Objective To evaluate the efficacy of Pseudomonas aeruginosa agent in treatment of malignant pleural effusion or malignant hydropericardium. Methods Twenty-six patients with malignant pleural effusion or malignant hydropericardium were enrolled. After drainage of effusion by inserting cavity central venous catheter into thoracic cavity or perieardial cavity, all patients were injected with 2-5 ml of Pseudomonas aeruginosa agent, 5 mg of dexamethasone, and 10 ml of 2% lidocaine. The drainage tube was closed for 48 hours and then opened later. The Pseudomonas aeruginosa agent was reused for one or two more times according to the drain amount. Results The effective rate was 90.0% （ 18 out of 20 patients） for the malignant pleural effusion and 100% （all the 10 patients ） for the malignant hydropericardium. The adverse effects included chest pain, shortness of breath and fever. Conclusion Intracavitary administration of Pseudomonas aeruginosa agent is an effective method for the treatment of malignant pleural effusion or malignant hydroperieardium.

关 键 词：恶性胸腔积液 恶性心包积液 铜绿假单胞菌注射液 

分 类 号：R730.5[医药卫生—肿瘤]