食管癌细胞DNA含量和细胞周期的分析  

Flow Cytometric Nuclear DNA Content and Cellular Cycle Analysis of Esophageal Carcinoma

作　　者：张冬成[1] 陈秉燮[1] 卢诗杰[1] 梅品超 

机构地区：[1]汕头大学医学院附属肿瘤医院胸外科 [2]汕头大学医学院中心实验室

出　　处：《汕头大学医学院学报》1998年第4期7-9,共3页Journal of Shantou University Medical College

摘　　要：报道100例食管瘤手术切除新鲜标本组织的DNA含量和细胞周期的流式细胞光度分析。结果显示癌细胞DNA非整倍体（AN）检出率为70．7％，细胞增殖指数（PI）为（20．79．1）％（xS）；非整倍体肿瘤S期细胞比例和PI显著高于二倍体肿瘤（P＜0．05和P＜0．01）。食管癌AN与肿瘤细胞分化和局部淋巴结转移密切相关（P＜0．05和P＜0.01）。食管癌流式细胞的DNA含量和细胞周期的分析在揭示肿瘤恶性生物学行为、指导临床治疗方面具有重要的意义。Flow cytometric nuclear DNA content and cellular Cycle analyses were Performed onesophageal careinoma from 100 patients. The result indicates that DNA aneuploidy (AN) was idenhfiedin 70.7% of patient, the proliferation index (PI) was (22.7 1 9. 1 ) (x s). S -- Phase fraction andPI of aneuploid tomor were significantly higher lean those of diploid tumor (P < 0.05). AN was foundto closely correlate with hath tumor cell differenhation and the frequency of lymph 'the metaStaSes (P <0.05 and P < 0.01 ). Thus, flow cytometric DNA content and cellular Cycle analysis Of esopllageal carcinoma are valued method indetermining the highly malignant potential and detecting clinical therapy.

关 键 词：食管癌 流动血细胞计数 DNA含量 细胞周期 

分 类 号：R735.102[医药卫生—肿瘤]