东方田鼠实验动物模型的建立及其在日本血吸虫病研究中的应用  

Progress in establishment of Microtus fortis experimental model and its application in the research of schistosomiasis japonicum

作　　者：费正弦[1] 袁忠英[1] 胡媛[1] 曹建平[1] 

机构地区：[1]中国疾病预防控制中心寄生虫病预防控制所、世界卫生组织疟疾、血吸虫病和丝虫病合作中心

出　　处：《国际医学寄生虫病杂志》2010年第1期53-58,共6页International JOurnal of Medical Parasitic Diseases

基　　金：国家自然科学基金（30872212,30371262,30771880）;国家863计划（2006AA022Z44）;上海市科委生物医药重点课题（064319026）

摘　　要：东方田鼠是我国非常有价值的野生动物资源之一。东方田鼠实验动物模型的建立已被列为国家的有关研究项目并得到了广泛全面的研究。日本血吸虫病是重要的人兽共患寄生虫病，仍是我国一个重要的公共卫生问题。而东方田鼠是迄今为止唯一发现具有天然抗血吸虫病的哺乳动物。目前，在东方田鼠生物学特性、实验动物化研究、分子遗传学研究方面均有一定的进展，以期为东方田鼠的抗日本血吸虫特性研究提供理想的动物模型。该文就东方田鼠实验动物模型的建立及其在血吸虫病研究中的进展作一综述。Microtus fortis is a valuable resource of wild animals in China. To develop an experimental model of Microtus fortis has been listed as a research project in national program and under extensive study. Up to date, schistosomiasis japonicum is an important zoonosis, which remains an important public health issue in China. Microtusfortis is a unique wild mammalian resistant to schistosomiasis so far. At present, more intensive studies are needed in its taxonomy, anatomy, purification, embryo cryopreservation and transplantation, especially in molecular genetics to develop a useful experimental model for researches on the resistant mechanism to S. japonicum infection and transgenic breeding of schistosomiasis-resistant animal in laboratory. In this paper, the progress in establishment of Microtus fortis experimental model and its application in the research of schistosomiasis japonica were reviewed.

关 键 词：东方田鼠 抗血吸虫病 动物模型 

分 类 号：R-332[医药卫生] R532.21