淋系血液肿瘤患者BAFF和APRIL表达及意义  

Expression and Significance of BAFF and APRIL in Patients with Lymphocyte-related Malignant

作　　者：潘湘涛[1] 陆晔[1] 王金湖[1] 程旭[1] 李蓉[1] 严敏[1] 

机构地区：[1]苏州大学附属太仓医院,江苏太仓215400

出　　处：《现代检验医学杂志》2010年第1期74-76,共3页Journal of Modern Laboratory Medicine

摘　　要：目的研究B细胞激活因子（BAFF）和增殖诱导配体（APRIL）在淋系血液肿瘤的表达情况及其临床意义。方法应用双抗夹心ELISA方法检测20例淋系血液肿瘤、17例髓系血液肿瘤患者和对照组25名健康献血员的血清BAFF和APRIL水平，并进行相关分析。结果①淋系血液肿瘤组的血清BAFF和APRIL分别为3．66±1．92ng／ml和38．29±24．99ng／ml，均明显高于对照组的2．90±0．52ng／ml和17．97±4．96ng／ml（分别为q=3．50，P〈O．05和q=4．85，P〈0．01），也高于髓系血液肿瘤纽的2．96±0．93ng／ml扣18．43±8．39ng／ml（分别为q=3．22，P〈0．05和q=5．19，P〈0．01）。②髓系血液肿瘤组的BAFF扣APRIL水平则与对照组无明显差异（分别为q=0．21和q=0．10，均为P〉0．05）。③淋系血液肿瘤组血清BAFF和APRIL水平呈正相关（r=0．5484，t=2．7838，P〈0．01）。而髓系血液肿瘸组扣对照组血清BAFF和APRIL水平均无相关关系（分别为r=0．0963和-0．2170，均为P〉0．05）。结论淋系血液肿瘤患者的BAFF和APRIL均高表达，可能是B细胞相关疾病发生机制的重要原因之一。Objective To study the expression and significance of B-cell activating factor（BAFF） and a proliferation-inducing ligand （APRIL） in patients with lymphocyte-related malignant. Methods To test the serum levels of BAFF and APRIL in 20 patients with lymphocyte-related malignant, 17 patients with myelogenous-related malignant and 25 cases ofcontrol group by ELISA. Results （1）The serum levels of BAFF in patients with lymphocyte-related malignant were higher than control group（3.66±1.92 ng/ml vs 2.90±0. 52 ng/ml,q=3.50,P〈0.05）,and the serum levels of APRIL were higher than control group（38. 29±24.99 ng/ml vs 17.97±4.96 ng/ml ,q=4.85,P〈0. 01）. The serum levels of BAFF and APRIL in patients with lymphocyte-related malignant were higher than levels of patients with myelogenous-related malignant,which were 2.96±0.93 ng/ml and 18.43±8.39 ng/ml respectively（q= 3.22,P〈0.05 and q=5.19,P〈0. 01. （2）The serum levels of BAFF and APRIL in patients with myelogenous-related malignant were no significance compared to control group（P〈0.05）. （3）There were positive relation both BAFF and APRIL in patients with lymphocyte-related malignant （r = 0. 548 4 ,t= 2. 783 8 ,P〈0. 01 ）. But ,there were no relation both BAFF and APRIL in patients with myelogenous-related malignant and in control group （r=0. 548 4 and -0. 217 0,P〉0. 05）. Conclusion The expression of BAFF and APRIL in patients with lymphocyte-related malignant may be one of factor contributed the B cell-related malignant.

关 键 词：淋系血液肿瘤 B细胞激活因子 增殖诱导配体 

分 类 号：R730.45[医药卫生—肿瘤]