低度恶性子宫内膜间质肉瘤临床病理分析  

The clinicopathologic analysis of low-grade endometrial stromal sarcoma

作　　者：陈任生[1] 熊秋迎[1] 盛以芸[1] 

机构地区：[1]南昌大学第一附属医院,南昌330006

出　　处：《江西医药》2010年第2期99-101,共3页Jiangxi Medical Journal

摘　　要：目的探讨低度恶性子宫内膜间质肉瘤(LESS)的临床病理学特征、诊断和鉴别诊断。方法分析16例LESS的临床病理特点,通过网状纤维染色、免疫组化染色研究其病理学特征。结果患者年龄26～68岁,平均42.5岁。LESS临床上主要表现为不规则的阴道流血。肿瘤组织成舌状浸润肌层,肿瘤细胞类似增殖期子宫内膜间质细胞。肿瘤内内有大量的似螺旋小动脉血管。网状纤维染色见网状纤维丰富,围绕瘤细胞生长。肿瘤细胞15例CD10阳性,14例ER阳性,15例PR阳性,5例actin阳性,CD34、CD117、Melan-A肿瘤细胞均阴性。结论LESS易误诊,确诊主要依靠组织病理学和免疫组织化学;病理形态上看似良好的低度恶性子宫内膜间质肉瘤,预后不一定好。Objective To investigate the clinicopathologic features, diagnocis and differential diagnosis of low-grade endometrial stromal sarcoma（LESS）.Methods Sixteen cases of LESS were analyzed by means of reviewing the history records,observing on both reticular fiber and immunohistochemical staining.The clinicopatological features of the LESS were studied and these cases were followed-up . Results The patients were from 26 to 68 years old （mean age 42.5 years） . The main clinical symptom of these patients was irregular vaginal bleeding. The tumor tissue presented ligulate invasion reaching the muscular layer, the tumor cell resembled the endometrial stromal cell of proliferation phase. There were a lot of blood vessels just like the spiral in the tumors. There were affluent of reticular fiber surrounding the tumor cell. The positive cases of CD10, ER, PR and actin were 15,14, 15 and 5 cases respectively, all of cases about CD34 , CDll7 and Melan-A were negative. Conclusion LESS is easy to misdiagnose, the diagnosis relies mainly on histopthological and immunohistochemical findings. The prognosis of LESS can be disaccord with pathological morphous.

关 键 词：子宫肿瘤 肉瘤 子宫内膜间质 病理学 

分 类 号：R737.33[医药卫生—肿瘤]