牛关节软骨复合物对佐剂性关节炎的治疗作用  

Therapeutic Effects of Bovine Articular Cartilage on Adjuvant-induced Arthritis

作　　者：刘安军[1] 安磊[1] 陈影[1] 朱振元[1] 陈汝洁[1] 

机构地区：[1]天津科技大学食品工程与生物技术学院,天津300457

出　　处：《现代食品科技》2010年第2期122-125,共4页Modern Food Science and Technology

基　　金：国家自然科学基金项目(20776113)

摘　　要：本文系统考察了牛关节软骨复合物对类风湿性关节炎的治疗作用。采用弗氏完全佐剂皮下注射左后足跖建立小鼠佐剂性关节炎模型,主要考察了牛关节软骨复合物、牛关节软骨多糖及牛喉管骨软骨多糖对模型小鼠关节指数、肝指数、脾指数和胸腺指数的影响,并检测了小鼠血清中超氧化物歧化酶(SOD)、丙二醛(MDA)、一氧化氮(NO)和白细胞介素(IL-1β)含量的变化。实验结果表明,牛关节软骨复合物可有效缓解小鼠关节肿胀现象,显著降低小鼠肝指数,胸腺指数,MDA,NO(P<0.05)及IL-1β(P<0.01)的含量,对佐剂性关节炎具有明显的治疗作用,且治疗效果优于软骨多糖组。关节软骨复合物为治疗类风湿性关节炎提供了一种新的药物选择。The therapeutic effects of bovine articular cartilage on adjuvant-induced arthritis in Kunming mice were investigated in the present study. Animals were divided into control group, model group and treatment groups （bovine articular cartilage, polysaccharide from bovine articular cartilage, polysaccharide from bovine laryngeal cartilage; administered orally by gastric intubations, 180 mg/kg/d, for 20 days after induction）. The arthritis model was induced by injection of Freund＇s complete adjuvant （FCA） into the left hind footpad. Arthritis index as well as the index of liver, spleen and thymus was analyzed. Corresponding kits were used in determining superoxide dismutase （SOD）, malondialdehyde （MDA）, nitric oxide （NO） and interleukin-1β （IL-1β） levels in serum. The results indicated that bovine articular cartilage could obviously attenuate the paw swelling response. Liver and thymus index, MDA and NO levels were significantly （P〈0.05） lowered by bovine articular cartilage-treatment. The serum level of IL-1β was significantly （P〈0.01） decreased by the treatment. Our results indicated that bovine articular cartilage had a therapeutic effect on adjuvant-induced arthritis and its efficacy was higher than those of polysaccharide groups. Bovine articular cartilage may be a viable therapeutic candidate for the treatment of rheumatoid arthritis.

关 键 词：牛关节软骨复合物 软骨多糖 佐剂性关节炎 超氧化物歧化酶 丙二醛 一氧化氮 白细胞介素IL-1β 

分 类 号：R285.5[医药卫生—中药学]