血管性帕金森综合征和帕金森病患者血中微量元素的变化  

Investigation on the Level of Trace Elements in Blood for the Patients with Vascular Parkinsonism and Parkinson's Disease

作　　者：张巍[1] 雷征霖[2] 陈海波[3] 

机构地区：[1]首都医科大学附属北京天坛医院神经内科,北京市100050 [2]大连医科大学附属一院神经内科 [3]大连医科大学中心实验室

出　　处：《中国卒中杂志》2010年第1期37-41,共5页Chinese Journal of Stroke

摘　　要：目的研究血管性帕金森综合征(vascular parkinsonism,VP)和帕金森病(Parkinson’s disease,PD)患者血中微量元素铜(Cu)、硒(Se)、锌(Zn)和铅(Pb)水平的变化。方法选择20例VP、17例PD患者和10例对照者,采用石墨炉原子吸收分光光度法检测血清Zn、Cu和全血Pb水平,采用荧光分光光度法检测血清Se水平,并进行分析。结果 (1)VP和PD组血清总体Cu和Se水平均明显高于对照组(P<0.05),VP和PD组间无统计学差别(P>0.05)。(2)VP、PD组总体血清zn和全血Pb水平较对照组无统计学差别(P>0.05)。(3)VP组病程<5年的患者血清Cu、Se和Zn水平明显高于对照组(P<0.05),全血Pb水平与对照组无统计学差别(P>0.05);病程>5年的患者血清cu和zn水平明显低于对照组(P<0.05),血清Se和全血Pb水平与对照组无统计学差别(P>0.05)。(4)PD组Ⅰ—Ⅱ期患者血清Cu、Se和Zn水平明显高于对照组(P<0.05),全血Pb水平与对照组无统计学差别(P>0.05);Ⅲ—Ⅴ期患者血清Cu和全血Pb水平均明显高于对照组(P<0.05),血清Se和Zn水平明显低于对照组(P<0.05)。结论 VP和PD组血清总体Cu和Se水平明显升高;VP组病程<5年的患者血清Cu、Se和Zn水平明显升高,病程>5年的患者血清Cu和Zn水平明显降低;PD组Ⅰ—Ⅱ期患者血清Cu、Se和zn水平明显升高,Ⅲ—Ⅴ期患者血清Cu和全血Pb水平明显升高,血清Se和Zn水平明显降低。微量元素可能在VP和PD的发生、发展和转归中起重要作用。Objective The aim of the study is to investigate the level of four trace elements, including copper （Cu）, selenium （Se）, zinc （Zn） and lead （Pb） in blood for the patients with vascular parkinsonism （VP） and Parkinson＇s disease （PD）. Methods The level of Cu, Zn and Pb in blood were measured in 20 VP patients, 17 PD patients and 10 control subjects by graphite furnace atomic absorption spectrophotometer and Se in blood by fluorophotometry. Results （1） The total level of Cu and Se in blood were significantly higher than that of control group （P〈0.05） and no significant difference was found between VP and PD groups （P〉0.05）. （2） The total level of Zn and Pb in blood for VP and PD groups were not significantly different when compared with control group （P〉0.05）. （3） The level of Cu, Se and Zn in blood were all significantly higher than that of control group （P〈0.05） in VP patients with duration 〈5 years, whereas Cu and Zn were significantly lower than that of control group （P〈0.05） in those with duration 〉5 years. （4） The level of Cu, Se and Zn in blood were all significantly higher than that of control group （P〈0.05） in PD patients who were in stage of Ⅰ-Ⅱ, whereas Cu and Pb were significantly higher, and Se and Zn were significantly lower than that of control group （P〈0.05） in PD patients who were in stage of Ⅲ-Ⅴ. Conclusion The overall level of Cu and Se in blood were obviously high. Elevated levels of Cu, Se and Zn in blood were found in VP patients with duration 〈5 years and declined levels of Cu and Zn in those with duration 〉5 years. The enhanced levels of Cu, Se and Zn in blood were observed in PD patients who were in the stage of Ⅰ-Ⅱ, the increased levels of Cu and Pb, and dropped levels of Se and Zn were showed in those who were in stage of Ⅲ-Ⅴ. The trace elements might play a pivotal role in the pathogenesis, progression and prognosis of VP and PD.

关 键 词：帕金森障碍 帕金森病 微量化学 

分 类 号：R742.5[医药卫生—神经病学与精神病学] R284.1[医药卫生—临床医学]