血脑屏障与脑小血管病  

Blood-Brain Barrier and Cerebral Small Vessel Disease

作　　者：李伟[1] 李桂林[2] 王拥军[1] 

机构地区：[1]首都医科大学附属北京天坛医院神经内科,北京市100050 [2]首都医科大学附属北京神经外科研究所神经病理科

出　　处：《中国卒中杂志》2010年第2期164-167,共4页Chinese Journal of Stroke

摘　　要：脑小血管病是指主要累及直径400μm以下的脑微小动脉血管病,临床表现为无症状性脑梗死,各种腔隙综合征和血管性认知功能障碍,影像学表现为腔隙性脑梗死灶,脑白质缺血性损害,微出血及血管间隙扩大的多种病因性疾病。血脑屏障渗透性的改变与脑小血管病之间有着重要的关系,即血管内皮及相关结构功能障碍导致血脑屏障渗透性增加,造成血液成分漏出到血管周围组织和脑实质内,继发相应的病理生理改变,导致脑小血管病相关的影像学和病理变化。Cerebral small vessel disease is a Microangiopathic disease of a variety of causes, mainly involving the cerebral small artery about diameter of 400μm below. Clinical manifestations of cerebral small vessel disease as a static cerebral lesions, all kinds of lacunar syndrome and vascular cognitive impairment, imagings show lacunar infarct, white matter ischemic damage, micro-bleeding and vascular space to expand. Changes of blood-brain barrier permeability and cerebral small vessel disease have important relationships, namely, the dysfunctions of vascular endothelial and related structures leading to increased blood-brain barrier permeability, causing leakage of blood components to the tissues around blood vessels and brain parenchyma, secondary the corresponding pathophysiological changes, which leads to cerebral small vessel disease related to imaging and pathological changes.

关 键 词：脑动脉疾病 血脑屏障 渗透 病理过程 

分 类 号：R743.3[医药卫生—神经病学与精神病学]