低频经颅磁刺激对锂-匹罗卡品致大鼠性发作的影响  

Effect of low-frequency transcranial magnetic stimulation on epilepsy behavior in epilepsy rats induced by Lithium-Pilocarpine

作　　者：赵红宁 王晓明[2] 张军强[2] 余巨明[2] 赵晓琼[2] 黄敏[2] 黄慧[2] 胡建秀[2] 

机构地区：[1]河南镇平县人民医院,镇平474250 [2]川北医学院附属医院神经内科,神经电生理研究室,南充637000

出　　处：《中国实用神经疾病杂志》2010年第5期1-3,共3页Chinese Journal of Practical Nervous Diseases

基　　金：四川省青年基金资助项目(NO:04ZQ026-010);四川省重点科技项目(川科计2005-14号)

摘　　要：目的探讨低频经颅磁刺激对癫大鼠性发作的影响。方法根据不同刺激频率将大鼠随机分为刺激频率0Hz组(假刺激组)、0.3Hz组(0.3Hz组)、0.5Hz组(0.5Hz组)、0.8Hz组(0.8Hz组)、1.0Hz组(1.0Hz组),分组进行预处理后,制作氯化锂-匹罗卡品癫模型,观察各组造模后70min内性发作的潜伏期和性发作行为表现。结果0.3Hz组、0.5Hz组、0.8Hz组、1.0Hz组的性发作潜伏期均比假刺激组延长,差异均有统计学意义(P<0.05或P<0.01),其中0.5Hz组最长,0.5Hz组大鼠出现的性行为表现点头/甩尾、须动/头面抽动、前肢/后肢抽动、全身抽动、窜动的次数均比0.3Hz组、0.8Hz组、1.0Hz组少,整体发作程度轻,差异有统计学意义(P<0.05)。结论适量的低频经颅磁刺激可延缓癫发作潜伏期,减少癫发作次数,减轻癫发作程度,具有抗作用。Objective To study the effects of low-frequency transeranial magnetic stimulation on epileptic attack behavior in experimental epilepsy rats. Methods Rats were randomly divided into five groups. The acute epilepsy model was made by Lithium-Pilocarpine after pretreatment, the latent period and the performance of epilepsy seizures within 70 minutes after intrap- eritoneal injection of Pilocarpine were observed. Results The latency period in each of 0.3 Hz, 0.5 Hz, 0.8 Hz and 1.0 Hz group was prolonger than model group（P〈0.05 or P〈0.01）. The times of epileptic attack behavior in 0.5 Hz group including nodding/tail-flick, beard shaking, anterior/hind limb tic, systemic tic and jump were less than those of model group respectively （P〈0.05 or P〈0.01） ,and the whole seizure level was less than that of model group,too（P〈0.05）. Conclusion Appropriate transcranial magnetic stimulation could prolong the latent period of epilepsy seizures, diminish the symptom and level of epilepsy attack, and has conspicuous anti epilepsy effect.

关 键 词：经颅磁刺激 癫痫 潜伏期 痫性发作 锂-匹罗卡品 

分 类 号：R-33[医药卫生]