多囊卵巢综合征患者血清IL-1Ra、IL-1β和IL-18水平的变化  

Serum Levels of Interleukin-1 Receptor Antagonist,Interleukin-1β and Interleukin-18 in Patients with Polycystic Ovarian Syndrome

作　　者：邵挥戈[1] 黄干[2] 

机构地区：[1]湖南省长沙市中心医院内分泌科,湖南长沙410004 [2]中南大学湘雅二医院内分泌科

出　　处：《实用预防医学》2010年第3期463-465,共3页Practical Preventive Medicine

摘　　要：目的研究多囊卵巢综合征(Polycystic ovarian syndrome,PCOS)患者血清中白细胞介素-1受体拮抗剂(IL-1Ra)、白细胞介素-1β(IL-1β)和白细胞介素-18(IL-18)水平,为阐明PCOS的发病机制提供基础。方法设POCS和健康对照两组,采用酶联免疫吸附法(Enzyme-linked immunosorbent assay,ELISA)或化学发光法(chemilumines-cent immunoassay)检测87例PCOS患者组以及85例年龄和体重指数(Bodymass index,BMI)相匹配的健康对照组血清IL-1Ra、IL-1β、IL-18、性激素水平以及内分泌代谢指标。结果1.PCOS组空腹胰岛素(Fasting insulin,FINS)、胰岛素抵抗指数(Homeostatic model assessment for insulin resistance,HOMA-IR)、睾酮(Testosterone,T)、黄体生成素(Lutein-izing hormone,LH)以及泌乳素(Prolactin,PRL)水平高于健康对照组(P<0.05～0.001),而卵泡刺激素(Follicle-stimu-lating hormone,FSH)水平低于健康对照组(P=0.007)。2.PCOS组血清的IL-1Ra、IL-1β和IL-18水平均显著高于健康对照组[PCOS组分别为:(275.3±55.1)pg/ml、(29.2±5.1)pg/ml和(258.6±39.8)pg/ml,健康对照组分别为:(167.2±50.3)pg/ml、(12.6±3.3)pg/ml和(143.1±22.4)pg/ml,P<0.001],而IL-1Ra/IL-1β比值显著低于健康对照组[PCOS组为9.6±1.5,健康对照组为13.3±1.3,P<0.001]。3.控制BMI影响后的偏相关分析显示,PCOS组血清IL-1Ra、IL-1β和IL-18水平与FINS、HOMA-IR呈正相关(r=0.278～0.463,P均<0.05),IL-1Ra/IL-1β比值与HO-MA-IR呈负相关(r=-0.293,P<0.05)。结论PCOS患者体内炎症因子水平增高、调控失衡。IR独立于肥胖,作为关键因素导致了PCOS的发生与发展。Objective To investigate the serum levels of interleukin-1 receptor antagonist （IL-1Ra）,interleukin-1β （IL-1β） and interleukin-18 （IL-18） in patients with polycystic ovarian syndrome（PCOS）,and to provide a basis for understanding the pathogenesis of PCOS. Methods PCOS group （n=87） and healthy control group （n=85） were included in this study,they were matched in the age and body mass index （BMI）. Serum IL-1Ra,IL-1β,IL-18,sex hormone levels and metabolic parameters were measured by enzyme-linked immunosorbent assay （ELISA） or chemiluminescent immunoassay. Results Serum levels of fasting insulin （FINS）,homeostatic model assessment for insulin resistance （HOMA-IR）,testosterone （T）,luteinizing hormone （LH） and prolactin （PRL） in PCOS group were significantly higher than those in healthy control group （P0.05～0.001）,but the level of follicle-stimulating hormone （FSH） in PCOS group was lower than that of healthy control group （P=0.007）. The serum levels of IL-1Ra,IL-1β,and IL-18 in PCOS group were significantly higher than those in healthy control group （PCOS group：275.3±55.1 pg/ml,29.2±5.1 pg/ml,and 258.6±39.8 pg/ml,respectively; healthy control group：167.2±50.3 pg/ml,12.6±3.3 pg/ml,and 143.1±22.4 pg/ml,respectively; P0.001）,but the IL-1Ra/IL-1β ratio was significantly lower in PCOS group than that in healthy control group （PCOS group：9.6±1.5,healthy control group：13.3±1.3,P0.001）. Serum IL-1Ra,IL-1β and IL-18 levels were positively correlated with FINS and HOMA-IR levels （r=0.278～0.463,P0.05）,and the IL-1Ra/IL-1β ratio was negatively correlated with HOMA-IR level in PCOS group （r=-0.293,P0.05） after the influence of BMI was corrected in the covariance analysis. Conclusions There are higher levels and inordinate inflammatory factors in the PCOS patients. IR which separates from obesity plays a key role in the development and progression of PCOS.

关 键 词：多囊卵巢综合征 白细胞介素-1受体拮抗剂 白细胞介素-1 白细胞介素-18 

分 类 号：R737.31[医药卫生—肿瘤]