PSMA、PSA在前列腺腺癌组织中的表达及其与腺癌临床分期的相关性分析  

Expression of prostate specific membrane antigen and prostate specific antigen in prostatic adenocarcinoma tissue and its correlation with clinical stages of prostatic adenocarcinoma

作　　者：唐庆来[1] 姚茂银[2] 薛君[3] 惠继红[1] 柳发德[1] 

机构地区：[1]南京医科大学附属江宁医院泌尿外科,江苏南京211100 [2]东南大学附属中大医院泌尿外科,江苏南京210009 [3]南京医科大学第二附属医院泌尿外科,江苏南京210011

出　　处：《东南大学学报（医学版）》2010年第1期65-69,共5页Journal of Southeast University(Medical Science Edition)

摘　　要：目的:研究前列腺腺癌(Pca)组织中前列腺特异性膜抗原(PSMA)、前列腺特异性抗原(PSA)的表达差异,评价两者在Pca预后评估中的价值。方法:选取Pca患者70例,平均年龄(74.3±6.1)岁;前列腺增生(BPH)患者62例,平均年龄(72.1±6.1)岁。采用免疫组化法检测PSMA、PSA表达。结果:Pca患者PSMA、PSA表达阳性率分别为61.4%(43/70)、91.4%(64/70);BPH患者分别为9.7%(6/62)、90.3%(56/62)。PSMA在Pca与BPH中的表达差异有显著性(P<0.001),PSA在Pca与BPH中的表达差异无显著性(P>0.05)。PSMA、PSA表达对Pca的检出率差异有显著性(P<0.001)。采用Spearman等级相关分析显示,PSMA和PSA在Pca中的表达无相关性(P=0.606);Pca临床分期与PSMA表达呈正相关(r=0.66,P<0.001),而与PSA表达无相关性(P=0.683)。结论:PSMA和PSA均有较好的前列腺组织特异性,组织PSA在鉴别男性肿瘤来源时较PSMA存在一定的优势;在鉴别前列腺组织病变的良、恶性时,PSMA优于PSA。PSMA表达与Pca的临床分期存在相关性,是Pca预后评价的重要指标之一,而组织PSA表达未显示这一优势。Objective：To study the difference of expression of prostate specific membrane antigen（PSMA） and prostate specific antigen（PSA） in prostatic adenocarcinoma tissue and to evaluate their clinical value in the prognosis of prostate cancer.Methods：70 patients of prostatic adenocarcinoma（Pca） with an average age of（74.3±6.1） years old and 62 patients of benign prostate hyperplasia（BPH） with an average age of（72.1±6.1） years old were enrolled in this study.The expression of PSMA and PSA were determined by immunohistochemical staining.Results：Positive expression rates of PSMA and PSA in patients with Pca were 61.4%（43/70）,91.4%（64/70） respectively;and positive rates of PSMA and PSA in patients with BPH were 9.7%（6/62）,90.3%（56/62） respectively.The expression of PSMA between Pca and BPH（P0.001） was significantly different,but the expression of PSA between Pca and BPH（P0.05）was not significantly different.The detection rates of Pca between PSMA and PSA（P0.001） were significantly different.By spearman rank correlation analysis,expression of PSMA and PSA in Pca showed no correlation（P=0.606）.Clinical stages of Pca was positively correlated with the expression of PSMA（r=0.66,P0.001）,but not correlated with the expression of PSA（P=0.683） did not show any correlation.Conclusion：PSMA and PSA have better prostatic tissue specificity.Expression of PSA in identifying sources of tumors in males and has some advantages over that of PSMA,but in the differential diagnosis of prostatic tissue of benign and malignant,PSMA is better than PSA.Expression of PSMA,one of the important indicators in prognosis of Pca,has a positive correlation（r=0.66,P0.001） with clinical stages of Pca while the expression of PSA has not.

关 键 词：前列腺腺癌 前列腺特异性膜抗原 前列腺特异性抗原 免疫组织化学 临床分期 

分 类 号：R737.25[医药卫生—肿瘤] R730.45[医药卫生—临床医学]