真空小梁成形术对原发性开角型青光眼及高眼压症的降眼压作用的初步研究  

The efficacy of pneumatic trabeculoplasty in primary open-angle glaucoma and ocular hypertension

作　　者：乔利亚[1] 梁远波[1] 卢清君[1] 唐炘[1] 彭忆[1] 陈虹[1] 郭淑珍[1] 王宁利[1] 

机构地区：[1]首都医科大学附属北京同仁医院北京同仁眼科中心北京市眼科研究所北京市眼科学与视觉科学重点实验室,100730

出　　处：《眼科》2010年第1期33-36,共4页Ophthalmology in China

摘　　要：目的观察真空小梁成形术(PNT)对国人原发性开角型青光眼(POAG)及高眼压症患者的降眼压效果。设计前瞻性病例系列。研究对象北京同仁医院2008年11月至2009年2月就诊的POAG及高眼压症患者30例(30眼)。方法入选患者进行眼科一般检查、前房角镜及Humphrey视野检查,测量眼压(压平眼压计)。患者单眼或双眼进行PNT1000型治疗仪(Oph-thalmic International公司产)治疗。治疗后1小时、1天、1周、2周、1个月、2个月复查。首次治疗后第7天重复治疗一次。单眼治疗者选治疗眼,双眼者随机选1眼,进行重复测量的方差分析。主要指标眼压。结果30例患者治疗前眼压(23.2±5.3)mmHg,平均应用局部降眼压药物1.47种(0～5种),治疗后1天、1周、2周、1个月、2个月各时间点眼压分别为(20.0±5.0)mmHg、(19.8±3.8)mmHg、(19.7±4.0)mmHg、(19.3±3.9)mmHg、(19.8±4.0)mmHg,眼压下降幅度分别为3.2mmHg、3.4mmHg、3.5mmHg、3.9mmHg、3.4mmHg,各时间点较治疗前眼压差异有统计学意义(P均<0.001)。23例(83%)治疗后眼压下降≥15%。结论本文的短期小样本研究显示,真空小梁成形术可安全有效地降低POAG及高眼压症患者的眼压。Objective To study the efficacy of pneumatic trabeeuloplasty （PNT） in paients with primary open-angle glaucoma and ocular hypertension. Design Prospective case series. Participants Thirty patients （30 eyes） with primary open-angle glaucoma or ocular hypertension in Beijing Touren Eye Center enrolled from November, 2008 to February, 2009. Methods All subjects underwent ophthalmologic slit lamp microscope, gonioseopy, Humphrey visual field examinations and intraocular pressure （lOP） measurement using applanation tonometer. One or two eyes of each one were treated with PNT Model 1000 （Ophthalmic International Inc.） at day 0 and 7. The ophthalmic slit lamp microscope examinations and IOP measurement were repeated at 1 day, 1 week, 2 weeks, l month and 2 months after PNT therapy. ANOVA of repeated measures was used. Main Outcome Measures Intraocular pressure. Results The lOP of pre-PNT was 23.2±5.3 mm Hg and the average number of eye drops for glaucoma was 1.47 （range 0-5）. The lOP of 1 day, 1 week, 2 weeks, 1 month and 2 months after PNT therapy were 20.0±5.0 mm Hg, 19.8±3.8 mm Hg, 19.7±4.0 mm Hg, 19.3±3.9 mm Hg and 19.8±4.0 mm Hg. The depression of IOP at each time of follow-up was 3.2 mm Hg, 3.4 mm Hg, 3.5 mm Hg, 3.9 mm Hg and 3.4 mm Hg, and the depression of lOP has the statistic significant （P〈0.001）. The lOP depression of 23 eyes （83%） was more than 15%. Conclusions This small sample study of PNT shows a potentially good IOP lowing effect on the primary open-angle glaucoma and hypertensive patients.

关 键 词：真空小梁成形术 原发性开角型青光眼 高眼压症 眼压 

分 类 号：R779.6[医药卫生—眼科]