阿立哌唑与氯丙嗪对精神分裂症患者生活质量影响的对照研究  

A Comparative Study on the Effects of Aripiprazole and Chlorphrenia Upon the Life Quality of Patients with Schizophrenia

作　　者：贡永宁[1] 郭平[1] 

机构地区：[1]河南省驻马店市精神病医院,463000

出　　处：《慢性病学杂志》2010年第3期209-210,共2页Chronic Pathematology Journal

摘　　要：目的:探讨阿立哌唑、氯丙嗪对精神分裂症患者生活质量的影响。方法:对符合CCMD-3诊断标准的精神分裂症患者分为阿立哌唑组(30例)与氯丙嗪组(为对照组30例)进行3个月的临床研究,用PANSS、WHOQOL-100分别评定患者的精神症状和生活质量。结果:3个月治疗后阿立哌唑组患者PANSS总分和阴性因子分改善优于氯丙嗪组;阿立哌唑对患者生活质量的影响除精神支柱外均有明显提高;氯丙嗪仅能部分提高患者的生活质量,但对患者的生活、心理和独立性领域没有明显改善。结论:阿立哌唑对精神分裂症患者的生活质量的改善优于氯丙嗪。Objective：To studty the respeltine effects of aripiprazole and chlorpromazine upon thelife quality of patients with schizophrenia. Methods：Two groups of patients conforming to the CCMD-3 diagnosis standard, with each consisting of 30 persons, werw treaeated and studied respectively with aripiprazoleand ehlorpromazine for a period of three months. Afterwards, the mental state and life quality of the two groups were separately evaluated with PANSS and WHO. QOL-100. Results： Through three months of treatment, the group taking aripiprazole acquired bigger improvements in terms of total PANSS score and negative factor scores. Chlorpromazine group had move adverse reactions than aripiprazole group. For the quetipine group,all the aspelts of life quality,except for spiritual pillar,were remarkably enhanced, while for the chlorpromazine group, but for partial life quality improvement, there were no notable achievements in the fields of physiology, psychology and independence. Condusion： Aripiprazole is superion to Chlorpromazine on the quality of life first-opisode schizophrenice.

关 键 词：喹诺酮类/治疗应用 哌嗪类/治疗应用 精神分裂症/药物疗法 氯丙嗪/治疗应用 生活质量 人类 

分 类 号：R749.305.3[医药卫生—神经病学与精神病学]