1,4-双(2-氰基苯乙烯基)苯的合成工艺改进  

Process improvement on the synthesis of 1,4-bis(o-cyanostyryl) benzene

作　　者：徐丽丽[1] 冯晓亮[1] 谢建伟[1] 赵颖俊[1] 

机构地区：[1]浙江工业大学浙西分校化学与制药工程系,浙江衢州324000

出　　处：《应用化工》2010年第3期456-458,462,共4页Applied Chemical Industry

基　　金：浙江省教育厅2008年度科研计划项目(Y200803501)

摘　　要：以对二甲苯为原料,通过氯化反应,用乌洛托品法水解氯化物合成对苯二甲醛,收率78.4%,含量99.5%。以二甲苯为溶剂,邻腈基苄基氯和亚磷酸三乙酯为原料,通过Abuzov反应合成邻氰基苄基膦酸二乙酯,收率86.5%。邻氰基苄基膦酸二乙酯通过Wittig反应和对苯二甲醛缩合制得1,4-双(2-氰基苯乙烯基)苯,收率84.1%,含量99.5%(HPLC)。1 ,4-Dimethylbenzene was chlorinated by dry Cl2 ,then the mixed chloride products was hydrolyzed to terephthalaldehyde by hexamethylenetetramine. The purity of the product was 99.5% and the yield is 78.4%. Diethyl o-eyanobenzyl phosphonate was synthesized by the esterification reaetion of trieth- yl phosphatidate and o-cyanobenzyl chloride dissolved in dimethylbenzene,the yield is 86.5%. 1,4-bis （o-eyanostyryl）-benzene was synthesized from diethyl o-eyanobenzyl phosphonate and terephthalaldehyde. The purity of the produet is 99.5% （HPLC） and the yield is 84.1%.

关 键 词：1  4-双(2-氰基苯乙烯基)苯 对苯二甲醛 邻氰基苄基膦酸二乙酯 WITTIG反应 

分 类 号：TQ610.495[化学工程—精细化工] O625.43[理学—有机化学]