围更年期焦虑抑郁患者的躯体症状群特征与血压、骨密度、认知水平的相关分析  

Analysis of the correlation between the syndrome characteristic and blood pressure, bone density, cognitive function in menopause anxiety-depression patients

作　　者：周伯荣[1] 邓燕华[1] 孙筱放[2] 许治强[1] 胡佳佳[1] 

机构地区：[1]广州医学院第三附属医院神经内科,510150 [2]广州医学院第三附属医院妇产科研究所,510150

出　　处：《中国神经免疫学和神经病学杂志》2010年第2期113-116,134,共5页Chinese Journal of Neuroimmunology and Neurology

基　　金：广东省自然科学基金资助项目(06022385)

摘　　要：目的探讨围更年期焦虑抑郁患者躯体症状群特征和血压、骨密度、认知水平的相关性。方法收集围更年期焦虑抑郁患者78例[再分为轻度症状组(35例)和明显症状组(43例)两个亚组]和无焦虑抑郁的更年期患者37例(对照组),采用Greene更年期症状量表调查患者的症状群特征,分析焦虑抑郁患者的动态平均血压、骨密度、认知功能、心理症状评分(HAMD、HAMA)、是否绝经与症状之间的相关性。结果 (1)3组动态平均血压、骨密度、认知功能比较无统计学差异;根据Greene更年期评分量表焦虑抑郁组的两个亚组焦虑症状群、抑郁症状群、躯体症状群评分较对照组明显升高(P<0.01)。(2)焦虑抑郁组Greene量表躯体症状群的总体评分与动态平均血压、骨密度无相关性(P>0.05),与抑郁、焦虑(HAMD、HAMA)密切相关(r分别为0.525、0.452,P<0.01);血管舒缩症状与平均收缩压、舒张压无相关性(P>0.05),第15～17项评分(肌肉或关节疼等)与骨密度无相关性(P>0.05);第6项(注意力障碍)与认知功能呈负相关(r=-0.278,P<0.05),与HAMD、HAMA呈正相关性(r分别为0.392、0.324,P<0.05)。结论围更年期的焦虑抑郁患者躯体症状群突出,躯体症状群与血压水平、骨密度下降无明显相关性,而与心理疾病相关。Objective To analyze the correlation between the syndrome characteristic and blood pressure, bone density and cognitive function in menopause anxiety-depression patients. Methods Seventy-eight anxiety-depression patients were collected and were divided into two groups, the slight symptom group （35 cases） and the overt symptom group （43 cases）, and the control group （non-anxiety-depression menopause patieats 37 cases）. Greene Climacteric Scale was adopted to measure the symptoms characteristics among the patients. The correlations between the syndromes, menopause and ambulatory mean blood pressure （MBP）, bone density, cognitive function analysis, psychological syndrome score （HAMD, HAMA） were examined. Results （1） There were no significant differences of the ambulatory MBP, bone density and cognitive function in three groups. The scores of somatization, depression and anxiety syndrome in Greene Climacteric Scale were higher in the anxiety depression group than in the control group （P〈0.01）. （2） The total score of somatization syndrome （12-18 item of Greene Scale） and the ambulatory MBP and bone density wasn＇ t related to （P〈0.05） and was closly related to HAMD or HAMA in anxiety-depression group （r=0. 525, 0. 452 respectively; P〈0.01）. In the anxiety-depression group, the corralation between vasoconstriction and the mean systolic pressure or diastolic pressure was not significant （P〉0.05）, meanwhile, the 15-17th items （muscle or articles pain symptoms ） of Greene Scale weren＇t correlated with the bone density （P〉0. 05） . The 6th symptom （attention disorder） showed an inverse correlation with cognitive function （r= -0. 278, P〈0.05） and positive association with the scoreof HAMD, HAMA in anxiety-depression group （r=0.392, 0.324, P〈0.05 ）. Conclusions The somatic symptoms were outstanding in menopause women with anxiety depression. The somatic ones were correlated with psychological disease, and not related to blood pressure, bone d

关 键 词：抑郁症 更年期 焦虑症 躯体症状群 高血压 骨密度 认知 

分 类 号：R749.42[医药卫生—神经病学与精神病学]