轻度认知功能障碍认知改变的“病例-病例”研究  

CASE-CASE STUDY OF MILD COGNITIVE IMPAIRMENT

作　　者：薛志林[1] 曲成毅[2] 马菲[2] 王婷[2] 银炯[2] 

机构地区：[1]山西大同大学御东校区医学院预防教研室,大同037009 [2]山西医科大学公共卫生学院流行病学教研室

出　　处：《现代预防医学》2010年第6期1001-1003,共3页Modern Preventive Medicine

基　　金：国家自然科学基金项目(30571611)

摘　　要：[目的]通过对社区老年人的横断面调查,以探究社区老年人轻度认知功能障碍者的流行病学分布特征和认知改变的地区差异。[方法]于2006年9-12月,用典型抽样法抽取太原市矿区和大同市矿区60岁及以上老年人作为研究对象,进行基线调查。调查内容包括一般情况、认知功能和生理指标。太原矿区共凋查1713人,从中筛出轻度认知功能障碍（MCI）患者作为一组病例来源,大同矿区共调查1420人,从中筛出MCI患者作为另一组病例来源,经年龄性别匹配后进行不同地区（太原-大同）的病例-病例研究。资料用SPSS11.0软件包进行统计分析。[结果]太原市矿区MCI患病率为5.43%,大同地区MCI患病率为5.77%;不同地区间病例比较结果显示：知识（t=4.305,P=0.000）、算术（t=2.454,P=0.016）、填图（t=2.419,P=0.018）、短期视觉记忆（t=3.026,P=0.003）几个方面的差异有统计学意义。[结论]两地区间MCI患病率不同,在不同地区同质MCI的认知功能改变存在一定差异,故制定不同区域MCI预防措施时应考虑不同侧重点。[Objective] To observe the epidemic distribute of the Mild Cognitive Impairment （MCI）, and explore the relation between zone and cognitive ability and the function of zone in predicting cognitive descending. [Methods] We made cross-sectional investigation among old people aged ≥60 years selected by typical sampling from September 2006 and December 2006 in the community of Taiyuan and Datong. The following items were investigated： cognitive examination, social demographic character investigation and physical examination. Among 1 713 people in the Taiyuan, we filter patients with MCI as a case group; Among 1 420 people investigated in Datong, we also selected patients with MCI as a case group. After matching for age and sex, we perform case-control study in different district. SPSS11.0 software was adopted for statistical analysis. [Results] Morbidity of MCI in Taiyuan was 5.43%, while the morbidity of Datong was 5.77%; The results of case to case comparison indicated： knowledge （t = 4.305, P = 0.000）, arithmetic （t = 2.454, P = 0.016）, charting （t = 2.419, P = 0.018） and short-term visual memory （t = 3.026, P = 0.003） showed statistical significance in the two zones. [Conclusion] The morbidi- ty and the cognitive descending of MCI in the two zones are different. We can formulate different preventive methods in the different zones.

关 键 词：轻度认知功能障碍 认知功能 分布 地区 

分 类 号：R749[医药卫生—神经病学与精神病学]