DLBCL中Survivin蛋白表达及其与bcl-2蛋白表达的相关性  

Expression of Surviving Protein in DLBCL and its Relationship with Expression of bcl-2 Protein

作　　者：何珏[1] 张文书[1] 杨庆春[1] 

机构地区：[1]赣南医学院病理教研室,江西赣州341000

出　　处：《赣南医学院学报》2010年第1期24-25,共2页JOURNAL OF GANNAN MEDICAL UNIVERSITY

摘　　要：目的:探讨Survivin蛋白在DLBCL中的表达及其与bcl-2蛋白表达的相关性。方法:采用免疫组化MaxVision法检测凋亡抑制基因Survivin在DLBCL和反应性增生的淋巴结组织中的表达及bcl-2蛋白在DLBCL中的表达。结果:Survivin蛋白在DLBCL中的阳性表达率为55.0%,在反应性增生的淋巴结组织中未见表达;bcl-2蛋白、Survivin阳性表达与患者的年龄、性别及肿瘤部位无关,bcl-2蛋白在DLBCL中的阳性表达率为50.0%。在DLBCL中,Survivin的表达与bcl-2蛋白表达密切相关。结论:在DLBCL中Survivin与bcl-2蛋白表达密切相关,二者协同发挥抗凋亡效应。Objective： To study the expression of surviving protein and its relationship with expression of bcl-2 protein in DLBCL. Methods： The expression of Surviving gene in DLBCL, reactive hyperplasia lymphoid node,and the expression of bcl-2 protein in DLBCL were detected by MaxVision immunohistochemicalmethod. Results： Survivin protein positive expression rate was 55.0% in DLBCL, and no expression was detected in reactive hyperplasia lymphoid nodes. The positive expression rate of surviving protein was nocorrelation with patients＇age, sex, histologicaltyping（WHO）. The positive expression rate of bcl-2 proteininos was 50.0% respectively. There was a significant correlationin expression between surviving protein, P glycoprotein and bcl 2 protein. Conclusions： The expression of survivin is closely correlated to that of bcl 2and they may play a synergic role in the course of anti-apeptosis.

关 键 词：DLBCL SURVIVIN蛋白 蛋白质BCL-2 免疫组织化学 

分 类 号：R730.231[医药卫生—肿瘤]