癌基因c-myc抑癌基因p53在涎腺肿瘤中的表达  

OVEREXPRESSION OF c myc ONCOGENE AND p53 TUMOURSUPPRESSOR GENE IN SALIVARY GLAND TUMOR

作　　者：陈建钢[1,2,3] 李辉[1,2,3] 毛永荣 喻伦银[1,2,3] 范崇德[1,2,3] 魏明波 

机构地区：[1]湖北医科大学附二医院 [2]湖北省肿瘤医院 [3]湖北医科大学病理解剖教研室

出　　处：《口腔颌面外科杂志》1998年第4期258-260,共3页Journal of Oral and Maxillofacial Surgery

摘　　要：方法：本文采用免疫组化（ＳＰ）法，研究了３０例涎腺肿瘤。目的：观察ｃ－ｍｙｃ癌基因和ｐ５３抑癌基因在涎腺肿瘤中的表达。结果：多形性腺瘤中，ｃ－ｍｙｃ和ｐ５３阳性率分别为５０．０％和２５．０％，均分别低于恶性肿瘤的阳性率７５％和５０．８％，两组比较均有高度显著性差异（Ｐ＜０．０１）。结论：ｃ－ｍｙｃ抑癌基因ｐ５３表达与涎腺上皮细胞增殖速度加快和突变有关，ｐ５３阳性率升高，虽与细胞恶变关系密切，但仅为判断细胞分化程度的一个参考指标。Objective:c myc and p53 proteins expression in salivary gland tumours. Methods: 30 cases of salivary gland tumor were detected by immunohistochemical method (SP). Results:the positive rates of c myc and p53 were 50.0% and 25.0%, these rates are lower than those of malignant tumours (75.0% and 50.8%). There are high differances between two groups( P <0.01). Positive stained cases of c myc overexpression were associated with cell proliferating cycle and cell mutation, p53 positive rate can only be a reference data for tumour cell growth and differentiation. Conclusion: The relation ship between expression of c myc and p53 with pathological diagnosis, tumour periods and clinic prognosis should be studied further.

关 键 词：涎腺肿瘤 癌基因 抑癌基因 表达 P53基因表达 

分 类 号：R739.870.2[医药卫生—肿瘤]