磁共振频谱数据定量后处理技术比较  

Comparison of three different post-processing techniques on the absolute quantitation of 1HMR spectroscopy

作　　者：郭绣琴[1] 肖叶玉[1] 沈智威[1] 徐志锋[1] 庞丽[1] 宁立波[2] 吴仁华[1] 

机构地区：[1]广东省汕头市汕头大学医学院第二附属医院影像科,515041 [2]广东省汕头市汕头大学工学院,515041

出　　处：《磁共振成像》2010年第2期126-129,共4页Chinese Journal of Magnetic Resonance Imaging

基　　金：广东省自然科学基金面上项目(81515031000032);广东省医学科研基金(B2008128)资助

摘　　要：目的比较磁共振频谱定量的三种常用后处理软件(LCModel、SAGE、Functool)对代谢物含量估计的准确性。方法14例健康成年人,平均年龄为26.1岁。使用STEAM序列进行定量检测,实验参数为TE=30ms,TR=3000ms。结果三种软件处理结果中除NAA/Cr外,Cho/Cr、mI/Cr的比值相互间存在差异。LCModel软件分析得到Cho/Cr比值与文献偏差明显。使用Functool软件进行分析发现,NAA/Cr、mI/Cr比值与文献结果间存在偏差。使用SAGE软件对频谱的波峰下面积分析并计算出比值,得出Cho/Cr、mI/Cr与文献结果存在差异。结论使用LCModel软件对于磁共振频谱进行定量处理,在基线的拟合及系统误差处理方面较SAGE软件及Functool软件有优势,但LCModel对代谢物浓度估算仍存在误差。Objective： To compare the accuracy of three different kinds of post- processing techniques： LCModel, Functool and SAGE software in the estimation of metabolite concentration. Materials and Methods： Fourteen health volunteers with an average age of 26.1 years old were selected for this study. All the 1HMR spectroscopy data were collected by STEAM sequence. The scan parameters were as followed： TE=30 ms, TR=3000 ms. Results： Except for NAA/Cr, the ratios of Cho/Cr and mI/Cr were significant different for the three post-processing technologies. Cho/Cr obtained from LCModel software was obviously deviated from the reference. NAA/Cr and mI/ Cr analyzed by Functool software were also deviated from the reference. What＇s more, the concentration translated from the peak areas through a known formula, Cho/Cr and mI/Cr were still deviated from the reference when we analyzed the spectrum by SAGE software. Conclusion： Compared with Functool and SAGE soflwares, LCModel software shows an advantage at the quantitation because of simulating the base-line spectrum and handling the systematic error. However, LCModel software was still weak at the calculation ofmetabolite concentration.

关 键 词：磁共振频谱学 STEAM LCMODEL Functool SAGE 定量 

分 类 号：R445.2[医药卫生—影像医学与核医学]