XRCC1多态性与豫北地区食管癌风险性关联研究  

Correlation of XRCC1 Codon 399 Polymorphisms and Risk of Esophageal Squamous Cell Carcinoma in North HeNan population

作　　者：赵文鹏[1] 路平[1] 苗战会[1] 徐芬[1] 

机构地区：[1]新乡医学院第一附属医院,河南卫辉453100

出　　处：《医学信息（中旬刊）》2010年第3期470-472,共3页Medical Information Operations Sciences Fascicule

摘　　要：目的:研究XRCC1单核苷酸多态性与豫北地区食管癌风险性的关系。方法:以PCR-RFL方法分析了食管癌病例(n=202)和按性别、年龄频数对照的正常对照者(n=317)XRCC1多态,并比较不同基因型与食管癌发生风险的关系。结果:Gln399Gln基因型在病例组和对照组中的频率分别为12.9%和6.3%,差异性显著(OR=2.117,95%CI=1.126～3.981;P<0.05)。结论:XRCC1Arg399Gln多态可能与豫北地区食管癌风险性有关。Objective ： The current study was designed to investigate the polymorphisms of XRCC1 in Northern HeNan esophageal squamous cell carcinoma （ ESCC ） and test the hypothesis which these genetic variation may have impact on the risk of ESCC. Methods： A case - control study of 202 ESCC patients and 317 control subjects（ matched for age,sex ）was conducted to investigate the role of XRCC1 in ESCC. Genotyping was performed using PCRRFLP. Results：The Gln399Gln genotype frequency in ESCC patients is higher than that in controls（ 12.9% ＆6. 3 % ）, have significant difference between cases and controls （ OR = 2.117,95 % CI =1.126 - 3.981 ; P 〈 0.05 ）. Conclusion ： the polymerphisms in XRCC1 Arg399Gln may have significant impact on the risk of ESCC.

关 键 词：XRCC1 食管肿瘤 单核苷酸多态性 

分 类 号：R394[医药卫生—医学遗传学]