肝癌基因治疗的机遇和挑战  

Opportunities and challenges in gene therapy of liver cancer

作　　者：钱程[1] 沈俊杰[1] 单娟娟[1] 

机构地区：[1]第三军医大学西南医院病理学研究所生物治疗研究室,重庆400038

出　　处：《中华消化外科杂志》2010年第1期12-14,共3页Chinese Journal of Digestive Surgery

基　　金：基金项目：国家重点基础研究发展计划（973计划.2010CB529406）;国家高技术研究发展计划（863计划,2006AA022126）;国家自然科学基金（30872984）

摘　　要：近年来，随着肝癌基因治疗研究的逐步推进，基于对治疗基因、载体以及给药方法的优化选择，经历了单独基因治疗，基因一病毒联合治疗两个阶段。但上述策略尚不能充分满足肝癌基因治疗的需求。细胞一基因．病毒联合治疗作为一种全新的基因治疗策略，联合发挥细胞、基因、病毒的三重治疗效果，是肝癌基因治疗新的发展方向。本文就肝癌基因治疗的研究进展、存在问题和发展方向做一阐述。Gene therapy has emerged as an efficient modality to treat human diseases. This method is based on the transfer of genetic material to tissues to induce a curative effect. Gene therapy vectors are molecular constructs used to facilitate the penetration of genomie sequences inside the cells. Viral vectors have however several limitations when administered directly to the patient. They may eanse significant toxicity by activating innate immunity or by eliciting an adaptive immune response against viral proteins. In addition, targeting the vector to the desired site is an issue when given systemically. The use of cells as vehicles for gene therapy vectors has many advantages. The combination of cell-viro-gene therapy has been thought as a new and promising strategy for therapy of cancer. The targeting vector to cancer stem cells will become a new direction in the field of gene therapy. In this article, we will introduce progressions, limitations and future directions of gene therapy of liver cancer.

关 键 词：肝肿瘤 基因治疗 

分 类 号：R735.7[医药卫生—肿瘤]