血浆内皮素、一氧化氮水平与牙周炎相关性的研究  

Correlation of plasma endothelin and serum nitric oxide levels with periodontitis

作　　者：王爱芹[1] 崔秀英[1] 孙继军[1] 舒静媛[1] 

机构地区：[1]滨州医学院附属医院口腔内科,山东滨州256603

出　　处：《牙体牙髓牙周病学杂志》2010年第2期65-67,共3页Chinese Journal of Conservative Dentistry

摘　　要：目的:通过观察牙周炎病人血浆内皮素(ET)和一氧化氮(NO)水平的变化,探讨与牙周炎发病可能的相关因素。方法:选择慢性牙周炎病人28人作为实验组,牙周健康者20人作为对照组。分别采集清晨空腹静脉血,分离血浆样本,采用放射免疫非平衡法直接测定各组血浆ET含量,采用硝酸还原酶法测定各组血浆NO水平,实验组经常规牙周基础治疗后4周,再次测定血浆ET和NO水平。结果:慢性牙周炎病人血浆ET和NO水平显著高于牙周健康者,二者差异具有统计学意义(P<0.05),慢性牙周炎组经基础治疗后,血浆ET和NO水平显著下降。血浆ET和NO水平与牙周炎严重程度具有正相关关系(P<0.05)。结论:慢性牙周炎病人血浆ET和NO水平显著高于牙周健康者,并与牙周炎严重程度具有相关性。AIM：To examine the plasma endothelin（ET） and nitric oxide（NO） levels in patieuts with chronic periodontitis and periodontical healthy people,and try to find out the possible relationship between the serum ET and NO levels with periodontitis.METHODS：Blood samples of 28 chronic periodontitis patients and 20 periodontic healthy volunteers were collected in the morning.Serum endothelin and NO levels were determined by homogeneous competitive radioimmunoassay and nitrate reductase method respectively.The ET and NO levels of periodontitis group were examined once again 4 weeks after periodontal treatment.RESULTS：Plasma ET and NO levels of periodontitis group were significantly higher than that of the healthy group（P〈0.05）.The severity of periodontitis and plasma ET and NO levels were statistically correlated（rET=0.839,rNO=0.819,P〈0.01）.The plasma ET and NO levels were significantly decreased after periodontal treatment（P〈0.01）.CONCLUSION：Our results indicated that the plasma ET and NO levels might be positively correlated with the severity of periodontitis.

关 键 词：血浆 内皮素 一氧化氮 牙周炎 基础治疗 

分 类 号：R780.2[医药卫生—口腔医学]