低频重复经颅磁刺激治疗精神分裂症顽固性幻听的随机双盲对照研究  

Treatment with 1Hz repetitive transcranial magnetive stimulation in auditory hallucination of schizophrenia:A double blind,randomized controlled trial

作　　者：任艳萍[1,2] 周东丰[1] 蔡焯基[2] 黄青[2] 卢苓[2] 陈琦[2] 

机构地区：[1]北京大学精神卫生研究所,卫生部精神卫生学重点实验室(北京大学),北京100191 [2]首都医科大学附属北京安定医院,北京100088

出　　处：《中国心理卫生杂志》2010年第3期195-197,205,共4页Chinese Mental Health Journal

基　　金：北京市科委基金(2003BA712A11-04)

摘　　要：目的:初步探讨双背侧前额叶低频重复经颅磁刺激(rTMS)治疗精神分裂症顽固性幻听的疗效和安全性,并观察其副反应。方法:25例伴顽固性幻听的精神分裂症患者随机分为rTMS治疗组(N=12)和对照组(N=13),分别给予10次1HzrTMS真刺激和伪刺激治疗,治疗期间维持原有抗精神病药种类及剂量不变。采用阳性和阴性症状量表(Positive and Negative Syndrome Scale,PANSS)评定临床症状,采用治疗中需处理的不良反应症状量表(Treatment Emergent Symptom Scale,TESS)等检查评估副反应。结果:25例患者均完成治疗,治疗组有效率高于对照组(75%vs.31%,P<0.05)。未观察到明显副反应。结论:1Hz双背侧前额叶低频重复经颅磁刺激治疗精神分裂症顽固性幻听可能有效,且安全性好,值得进一步研究。Objective： To examine the therapeutic effects of dual dorsolateral prefrontal repetitive transcranial magnetic stimulation （rTMS） on auditory hallucinations experienced by schizophrenic patients. Methods： A doub- le-blind randomized controlled study was conducted. Totally 25 schizophrenic patients met DSM-IV criteria for schiz- ophrenia and had anditory hallucination with stable antipsychotic drugs treatment were recruited. Subjects were grouped into active treatment subgroup and sham subgroup randomly. Measurements including the Positive and Nega- tive Symptom Scale （PANSS） for clinical symptom and the Treatment Emergent Symptom Scale （ TESS ） for side- effects were evaluated. Results： Totally 25 subjects completed the trial. The treatment efficiency of active treatment group was higher than that of sham group （75% vs. 31%） .No overt side effects of rTMS were observed. Conclusion： It is effective for rTMS to treat schizophrenia with auditory hallucination at 1Hz. rTMS may be a new selection of schizophrenia treatment

关 键 词：重复经颅磁刺激 精神分裂症 幻听 随机对照研究 

分 类 号：R749.305[医药卫生—神经病学与精神病学]