小剂量奥氮平联合文拉法辛治疗老年抑郁症77例疗效观察  

Efficacy of low-dose olanzapine combined with venlafaxine in the treatment of senile depression

作　　者：王定超[1] 李建红[1] 朱晓玲[1] 

机构地区：[1]成都市老年病医院神经内二科,四川成都611130

出　　处：《海南医学》2010年第6期11-12,共2页Hainan Medical Journal

摘　　要：目的探讨小剂量奥氮平联合文拉法辛治疗老年抑郁症的疗效和安全性。方法采用随机对照研究,将77例老年抑郁症患者随机分为两组,分别以文拉法辛组(单药组)和小剂量奥氮平联合文拉法辛组(联合组),分别在第2周、第3周、1个月末、3个月末行Zung自测抑郁量表评分,并观察药物不良反应。结果小剂量奥氮平联合文拉法辛组治疗老年抑郁症的疗效显著优于文拉法辛组(P<0.001),两组间药物不良反应无明显差异(P>0.05)。结论小剂量奥氮平联合文拉法辛治疗老年抑郁症的疗效显著优于单用文拉法辛,安全性高。Objective To observe the efficacy and safety of low - dose olanzapine combined with venlafaxine in the treatment of senile depression. Methods 77 eases of senile patients with depression are randomly assigned into two groups, venlafaxine group （monotherapy group） and lowdose olanzapine combined venlafaxine group （combined group）, all the patients were scored by Zung Self- Depression Scale in 2 weeks, 3 weeks, 1 month, 3 month after treatment respectively, meanwhile adverse drug reactions were observed. Results The efficacy of low - dose olanzapine combined venlafaxine group was significantly better than that of venlafaxine group in the treatment of senile depression （ P 〈0.001 ） , there was no significant difference of adverse drug reaction between two groups （ P 〉 0.05）. Conclusion Low - dose olanzapine combined venlafaxine is significantly better than venlafaxine alone in the treatment of senile depression.

关 键 词：老年抑郁症 奥氮平 文拉法辛 

分 类 号：R749.4[医药卫生—神经病学与精神病学]