紫外线对小型猪皮肤的影响以及积雪苷对紫外线所致光老化防护作用的研究  

To Study that Ultraviolet Ray Influence Minitype Pig Skin and Asiaticoside Protects Skin

作　　者：周梦云[1] 宋为民[2] 韩长元 潘虹[2] 樊奇敏[2] 许爱娥[2] 

机构地区：[1]浙江中医药大学,浙江杭州310053 [2]浙江中医药大学附属杭州第三人民医院,浙江杭州310009 [3]宁波市传染病医院,浙江宁波315010

出　　处：《中华中医药学刊》2010年第3期623-625,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：杭州市卫生局资助项目(2008B0042)

摘　　要：目的:建立皮肤光老化动物模型以及积雪苷霜软膏对光老化防护作用的研究。方法:采取高剂量中波紫外线和长波紫外线短期联合照射的方法,建立皮肤光老化的实验动物模型。每天每次照紫外光后的间歇,在紫外线照射区域的皮肤上外涂积雪苷霜软膏。结果:与正常皮肤区域和外涂积雪苷区皮肤相比较,紫外线照射区皮肤的含水量和皮肤弹性均下降,黑色素指数增高,差异有显著性(P<0.05);外涂积雪苷区,正常皮肤区域分别与紫外线照射区皮肤比较皮肤组织的羟脯氨酸含量,差异有显著性。结论:短期高强度的紫外线照射能够引起皮肤光老化的表现。积雪苷对紫外线照射所造成的光老化的损害的有修复和保护作用。Objectie：To establish the animal model of skin photoaging as well as to study protective effects asiaticoside.Methods：To take high doses of UVB and UVA irradiation a short-term joint approach,The establishment of skin photoaging of the experimental animal models. After each day according to the intermittent UV,ultraviolet radiation in the region treated with asiaticoside.Results：Compared with normal skin and the treated region of asiaticoside,compared to ultraviolet radiation and skin moisture content decreased skin elasticity,melanin index increased,there was a significant difference （P0.05）; treated with asiaticoside zone,the region of normal skin,respectively,ultraviolet radiation and skin comparison of skin hydroxyproline content,there was a significant difference.Conclusions：Short-term high-intensity ultraviolet radiation can cause the performance of skin photoaging. asiaticoside have repair and protection which caused by exposure to ultraviolet light damage.

关 键 词：皮肤光老化 皮肤生理功能 羟脯氨酸 积雪苷霜 

分 类 号：R-33[医药卫生]