口腔癌多药耐药的研究现状  

The Research Status about Multi-drug Resistance of Oral Cancer

作　　者：陆新萍[1] 王代友[1] 

机构地区：[1]广西医科大学附属口腔医院口腔颌面外科,南宁530021

出　　处：《医学综述》2010年第6期829-831,共3页Medical Recapitulate

基　　金：广西自然科学基金(桂科自0640095)

摘　　要：化疗是口腔癌临床治疗的常用方法之一,在口腔癌治疗中发挥了重要的作用。但部分病例化疗后出现疗效不佳现象,表现为机体对化疗药物出现了耐药现象。研究发现多数肿瘤细胞存在内源性和外源性的耐药,这是造成化疗失败的主要原因。相关研究表明口腔癌多药耐药与相关蛋白表达、酶类介导、基因突变等众多因素相关,目前研究热点是针对耐药相关因素进行多药耐药的逆转。Chemotherapy is one of the common methods of oral cancer clinical treatment. It plays an important role in oral cancer treatment. Drug-resistant phenomenon cause some of the cases occurred poor effect after chemotherapy. Researches found that most tumor ceils exist endogenous and exogenous of drug resistance, it is the main reason for the failure of oral cancer chemotherapy. The studies found that the muhi-drug resistance of oral cancer relates to the protein expression, enzyme-mediate, genetic mutations and many other factors. Currently,it becomes a hot spot to study the reverse for the resistance-related factors.

关 键 词：口腔癌 多药耐药 逆转 

分 类 号：R739.8[医药卫生—肿瘤]