依达拉奉对大鼠重症急性胰腺炎肺损伤的影响  

Effects of Edaravone on Lung Injury of Severe Acute Pancreatitis in Rats

作　　者：周粼[1] 梁道明[1] 陈嘉勇[1] 甘平[1] 张家骅[1] 

机构地区：[1]昆明医学院第二附属医院普外科,昆明650101

出　　处：《中国普外基础与临床杂志》2010年第2期152-155,共4页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的探讨依达拉奉(edaravone)对大鼠重症急性胰腺炎(SAP)肺损伤的影响。方法36只成年SD大鼠随机分为正常对照组、模型组及依达拉奉组,每组12只,经胰胆管逆行注射5%牛磺胆酸钠建立SAP大鼠模型。依达拉奉组给予依达拉奉,正常对照组和模型组则给予等量生理盐水。术后6h处死大鼠,检测其血清和肺组织匀浆中超氧化物歧化酶(SOD)活性、丙二醛(MDA)含量,血清中肿瘤坏死因子-α(TNF-α)及白介素(IL)-1、IL-6含量,并计算肺干/湿重比(D/W)。结果模型组血清及肺组织中MDA含量以及血清TNF-α、IL-1和IL-6水平均明显高于正常对照组及依达拉奉组(P<0.05),依达拉奉组血清及肺组织中MDA含量以及血清TNF-α、IL-1和IL-6水平也明显高于正常对照组(P<0.05);而模型组肺D/W、血清及肺组织中SOD活性则明显低于其他2组(P<0.05)。结论依达拉奉能减轻大鼠SAP导致的肺损伤。Objective To study the effects of edaravone on the lung injury of severe acute pancreatitis （SAP） in rats. Methods Thirty-six SD rats were randomly divided into three groups：normal control group,model group and edaravone group,and SAP was induced by intraductal administration of 5% sodium taurocholate. Edaravone was given in edaravone group,while normal saline was given in normal control group and model group. After operation 6 h rats were executed,and dry/wet weight （D/W） ratio of lung was counted,and malondialdehyde （MDA） content,superoxide dismutase （SOD） activity in serum and lung were detected,respectively. In addition,the levels of tumor necrosis factor-α （TNF-α）,interleukin-1,-6 （IL-1,-6） of serum were detected. Results The MDA content of serum and lung and the levels of TNF-α,IL-1,IL-6 in model group were markedly higher than those in normal control group and edaravone group,but D/W ratio of lung,SOD activity of serum and lung were significantly lower （P0.05）. Conclusion Edaravone can alleviate lung injury of rats caused by SAP.

关 键 词：依达拉奉 重症急性胰腺炎 肺损伤 大鼠 

分 类 号：R576[医药卫生—消化系统] R563.8[医药卫生—内科学]