二苯羟乙酸糖酯酶促合成研究  

Study on Enzymatic Synthesis of Sugar Esters of Benzilic Acid

作　　者：王宗君[1] 胡文祥[2] 张良军[1] 

机构地区：[1]广西工业职业技术学院,广西南宁530001 [2]军事医学科学院,北京100850

出　　处：《当代化工》2010年第1期17-19,共3页Contemporary Chemical Industry

摘　　要：二苯羟乙酸衍生物及糖类化合物分别具有重要的生理功能,二苯羟乙酸糖酯有可能同样具有一定的生理价值。着重对这类化合物的酶促合成进行探讨,选择定位合成二苯羟乙酸糖酯,收率达26%。The derivatives of benzilic acid and fructose are significan in life sciences. Carbohdrate molecules represent a particularly challenging target for regioselective modifications due to their multitive hydroxyl groups. The 1-fructopyranosyl benzilate was synthesized by enzyme-catalyzed regioselective etherification of fi＇uctose and actived esters of diphenyl glycolic acid in anhydrous pyridine with porcine pancreatic lipase.The yield of the product was 26%.

关 键 词：二苯羟乙酸糖酯 酶促合成 选择定位 

分 类 号：TQ464.1[化学工程—制药化工]