宫颈癌相关基因单核苷酸多态性研究进展  

Research Development of Single Nucleotide Polymorphisms in Related Gene of Cervical Cancer

作　　者：柴丹[1] 郑艾[1] 褚艳侠[1] 巩俊玲[1] 

机构地区：[1]四川大学华西第二医院妇产科,四川成都610041

出　　处：《中华妇幼临床医学杂志（电子版）》2010年第2期126-129,共4页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)

摘　　要：宫颈癌是妇科常见的恶性肿瘤之一。与机体遗传背景相关的基因多态性,被认为是决定人乳头瘤病毒(humanpa pilloma virus,HPV)感染后宫颈癌发病与否及预后的重要因素。单核苷酸多态性(single nucleotide polymorphisms,SNPs)是指某基因中人群发生率超过1%的单碱基替换或缺失现象。本文就近年来与宫颈癌相关的单核苷酸多态性的研究进展综述如下。Cervical cancer is one of the most common types of gynecologic malignant tumors. As the key influence factor, gene polymorphism plays an important role in the susceptibility, development and prognosis of cervical cancer after human papilloma virus （HPV） infection. Single nucleotide polymorphisms （SNPs） represents an alternate nucleotide in a given and defined genetic location at a frequency exceeding 1% in a given population. This paper reviewed the recent research development of single nucleotide polymorphisms in related gene of cervical cancer.

关 键 词：单核苷酸多态性 宫颈癌 易感性 化疗敏感性 

分 类 号：R737.33[医药卫生—肿瘤]