乳腺癌中bcl-2及nm23表达的研究  

EXPRESSION OF bcl 2 And nm23 In BREAST CANCER

作　　者：徐艳峰[1] 王美清[1] 李红[1] 

机构地区：[1]山东医科大学病理学教研室

出　　处：《山东医科大学学报》1998年第4期278-281,285,共5页Acta Academiae Medicinae Shandong

基　　金：山东省科委科研基金

摘　　要：为探讨抗凋亡基因ｂｃｌ－２及转移抑制基因ｎｍ２３对乳腺癌生物学行为的影响，对乳腺癌４０例进行了免疫组化检测。结果表明，ｂｃｌ－２表达与患者年龄、肿瘤大小、有无淋巴结转移无关，而与乳腺癌组织学分级呈负相关，高、中分化组ｂｃｌ－２表达率高于低分化组（Ｐ＝０．００４１）。ｎｍ２３低表达与淋巴结转移有关（Ｐ＜０．０５），也与乳腺癌低分化有关（Ｐ＝０．００７６）。ｂｃｌ－２与ｎｍ２３表达呈正相关。ｂｃｌ－２影响乳腺癌的分化，而ｎｍ２３除抑制肿瘤转移外，也与分化程度有关。乳腺癌中，ｂｃｌ－２和ｎｍ２３共同表达可能代表恶性程度较低的一种类型。The expression of bcl 2 and nm23 in 40 cases of human breast cancer were observed by immunohistochemical technique LSAB method. There was no significant correlation between bcl 2 expression and patient age, tumor size, or lymph node status. However, a significant inverse correlation was found between bcl 2 expression and histological grade. Low nm23 expression was associated with lymph node metastasis and high tumor grade. nm23 and bcl 2 expression are correlated. bcl 2 can affect breast cancer cells differentiation,nm23 may have effect on tumor cell differentiation as well as on metastasis.

关 键 词：乳腺肿瘤 基因表达 BCL-2 NM23 免疫组化 

分 类 号：R737.902[医药卫生—肿瘤]