前列腺癌组织神经内分泌细胞的免疫组化超微诊断及意义  

Ultrastructural and immunohistochemical study of neuroendocrine cells in prostatic carcinoma

作　　者：姚宏[1,2,3,4] 王秋锁[1,2,3,4] 姚巍[1,2,3,4] 袁瑞香 王虹平[1,2,3,4] 苏萍 赵玛丽 张庆升 纪小龙[1,2,3,4] 

机构地区：[1]太原市人民医院 [2]山西医科大学第三医院 [3]山西医科大学第二医院 [4]解放军总医院

出　　处：《中华泌尿外科杂志》1998年第12期736-739,共4页Chinese Journal of Urology

摘　　要：应用透射电镜技术对４０例前列腺癌、２０例前列腺增生症及１０例正常前列腺组织的神经内分泌（ＮＥ）细胞进行观察，并与抗嗜铬粒蛋白Ａ（ＣｇＡ）、神经元特异性烯醇化酶（ＮＳＥ）和６种激素抗体免疫组化技术进行对比观察。前列腺癌中含ＮＥ型癌细胞３２例，依据内分泌颗粒的形态不同可分为三种类型，前列腺增生症ＮＥ细胞的形态与正常前列腺组织相似，但数量有明显变化。对正常前列腺组织细胞的超微形态与功能。The neuroendocrine(NE) cells in fresh specimens of 40 prostatic carcinoma,20 benign prostatic hyperplasic (BPH) and 10 normal prostatic tissues(NP) were studied with transmission electron microscopy(TEM) and their immunohistochemical charatreristics were contrasted by using anti CgA,NSE and six kinds of hormonal antibody under TEM.Carcinomatous NE cell were found in 32 out of 40 cases with prostatic carcinoma.It is shown that the cellular and nuclear shapes were heteromorphic. Based on their different shapes of endocrine granules,the NE cells could be categorized into three types.The shape of NE cells in BPH was similar to that of the NP,but the number varied remarkably.The diagnostic features of ultrastructural pathological changes of NE cells and their functional alterations in prostatic carcinoma were discussed.

关 键 词：前列腺肿瘤 神经内分泌细胞 免疫组化 超微诊断 

分 类 号：R737.250.4[医药卫生—肿瘤]