TXB2、HCY和6-K-PGF1a对评估急性脑梗死疗效的价值  

Determination of Plasma Thromboxane B2,Homocysteine,and 6-keto-Prostaglandin F1a in Acute Cerebral Infarction

作　　者：孙安民 

机构地区：[1]河南省开封市第一人民医院,河南开封475000

出　　处：《中国现代医生》2010年第8期83-83,87,共2页China Modern Doctor

摘　　要：目的探讨血浆血栓素B2(TXB2)、同型半胱氨酸(HCY)和6-酮-前列腺素F1a(6-K-PGF1a)测定对急性脑梗死患者疗效观察的临床意义。方法对108例急性脑梗死患者治疗前和治疗后2周,采用放射免疫法测定血浆血栓素B2(TXB2)、6-酮-前列腺素F1a(6-K-PGF1a)浓度,采用微粒子酶免分析法测定治疗前后同型半胱氨酸(HCY)浓度,观察治疗前后患者血浆TXB2、6-K-PGF1a、HCY的浓度改变。结果急性脑梗死患者治疗后血浆TXB2及HCY明显下降(P<0.05),6-K-PGF1a明显升高(P<0.05)。结论通过测定血浆TXB2、6-K-PGF1a、HCY浓度,可以判断急性脑梗死的疗效,对治疗急性脑梗死有一定价值。Objective To investigate the determination of plasma thromboxane B2 （TXB2）, homocysteine （HCY） and 6-keto- prostaglandin F1a （6-K-PGF1a）,which has great clinical influence on the patients with acute cerebral infarction. Methods The levels of plasma TXB2 and 6-K-PGF1a were detected in 108 cases of acute cerebral infarction before treatment and 2 weeks after treatment by radioimmunoassay and their plasma HCY level was detected by microparticle enzyme immunoassay method before and after treatment and their level changes before and after treatment were observed. Results After treatment, the levels of plasma TXB2 and HCY were significantly decreased（P〈0.05） and the plasma 6-K-PGF1a level was significantly increased （P〈0.05）. Conclusion The curative efficacy of acute cerebral infarction can be determined by measuring the plasma TXB2,6-K-PGF1a and HCY levels, which is of great value in its treatment.

关 键 词：急性脑梗死 血栓素B2 6-酮-前列腺素F1A 同型半胱氨酸 

分 类 号：R743.32[医药卫生—神经病学与精神病学] R743.33[医药卫生—临床医学]