离体人氟斑牙脱矿与再矿化的研究  

Study on Demineralization and Remineralization of Human Fluorosed Teeth in Vitro

作　　者：罗丽娅[1] 黎红[2,3,1] 梁继超[1] 雷晓旭[1] 张慧[1] 彭生诚[1] 梁成文[1] 

机构地区：[1]四川大学口腔医学院口腔疾病研究国家重点实验室,成都610041 [2]浙江中医药大学第二临床医学院 [3]杭州口腔医院,杭州310053

出　　处：《生物医学工程学杂志》2010年第1期116-119,125,共5页Journal of Biomedical Engineering

基　　金：四川省科技支撑项目资助(2009FZ0065);教育部留学回国人员科研启动基金资助项目(2008890);国家自然科学基金重点项目资助(50535050)

摘　　要：通过研究不同严重程度人氟斑牙在体外经人工龋脱矿实验及再矿化处理前后,釉质表面显微硬度值的变化,探讨氟斑牙的严重程度与脱矿再矿化的关系。结果发现:脱矿后氟斑牙的表面显微硬度损失百分比(%SMHD)为TFI4(18.92±1.31)<TFI3(20.50±1.32)<TFI2(25.08±1.69)<TFI1(27.77±1.79)<TFI0(30.70±1.35),(P<0.05),轻度氟斑牙TFI1(27.77±1.79)与对照组正常牙TFI0(30.70±1.35)没有显著统计学差异。再矿化处理后氟斑牙的表面显微硬度恢复的百分比(%SMHR)为TFI1(55.17±4.03)>TFI0(53.97±4.96)>TFI2(49.17±3.11)>TFI3(44.85±3.21)>TFI4(36.51±2.95)(P<0.05);中重度氟斑牙的抗龋性显著高于轻度氟斑牙及正常牙,轻度氟斑牙再矿化的效果明显好于中重度氟斑牙,同时也比正常牙稍好。值得临床注意。This study sought to determine the impact of dental fluorosis severity on demineralization and remineralization of human fluorosed teeth in vitro.Surface enamel microhardness was measured on the enamel blocks before and after demineralization and after remineralization.The results showed that after demineralization,the sequence of % Surface microhardness demineralization（%SMHD）was TFI4（18.92±1.31）〈TFI3（20.50±1.32）〈TFI2（25.08±1.69）〈TFI1（27.77±1.79）〈TFI0（30.70±1.35）（P〈0.05）,and there was no statistically significant differences between TFI1（27.77±1.79） and the normal group TFI0（30.70±1.35）.After remineralization,the sequence of % Surface microhardness remineralization（%SMHR） was TFI1（55.17±1.23）〉TFI0（53.97±3.05）〉TFI2（49.17±1.81）〉TFI3（44.85±1.89）TFI4〉（36.51±2.95）（P〈0.05）.Moderately fluorosed enamel showed a significatnt resistance to caries,but mildly fluorosed enamel could get better remineralization.These facts and figures deserve clinicians＇ attention.

关 键 词：氟斑牙 人工龋 再矿化 显微硬度 

分 类 号：R78[医药卫生—口腔医学]