桥本脑病4例临床特点分析  

The analysis of the clinical features for four patients with Hashimoto's Encephalopathy

作　　者：秦雪[1] 何晶[2] 陈晏 李蕾[1] 祁俐[1] 邹蔷薇[4] 何志义[1] 

机构地区：[1]中国医科大学附属第一医院神经内科,沈阳博士研究生110001 [2]中国医科大学 [3]辽宁省金秋医院 [4]沈阳市红十字会医院

出　　处：《卒中与神经疾病》2010年第1期32-35,42,共5页Stroke and Nervous Diseases

摘　　要：目的探讨桥本脑病的发病机制、临床表现、实验室检查特点及预后。方法分析本院收治的4例桥本脑病患者的临床资料,观察其临床表现、实验室及影像学检查特点及治疗,并随访1～2年。结果4例患者均为女性,临床表现主要为认知功能障碍、行为异常、抽搐等。实验室检查患者血清抗甲状腺抗体水平明显增高。3例经大剂量糖皮质激素冲击治疗,患者症状较前缓解,随访无复发。结论桥本脑病是一种伴有抗甲状腺抗体水平增高、对激素反应良好的脑病综合征,一般预后良好。Objective To investigate the pathogenesis,clinical presentations,laboratory features and prognosis of Hashimoto＇s Encephalopathy（HE）.Methods We analyzed the clinical presentations,laboratory findings and treatment in 4 patients with HE who were admitted to our hospital,and followed up 1-2 years.Results 4 cases were all female.They mainly presented with cognitive dysfunctions,abnormal behaviors and seizures.We found that antithyroid antibodies were significantly higher.The symptoms of 3 cases improved after treatment of high dose steroids.Conclusions HE is an encephalopathy with the presence of elevated antithyroid antibodies and well response to steroids,with a good prognosis.

关 键 词：桥本脑病 抗甲状腺抗体 激素 自身免疫性疾病 

分 类 号：R742.89[医药卫生—神经病学与精神病学]