P16在乳腺癌及乳腺腺病中的表达及其临床意义  

Study of Expression of P16 in Breast Cancer and Adenosis

作　　者：魏茂富[1] 杨延莉[2] 刘镜文[1] 

机构地区：[1]东莞市虎门医院病理科,广东东莞523900 [2]东莞市虎门医院内三科,广东东莞523900

出　　处：《中国现代医生》2010年第7期138-139,共2页China Modern Doctor

摘　　要：目的探讨P16在乳腺癌及乳腺腺病中的表达变化与临床病理意义。方法应用免疫组织化学方法,分别检测乳腺癌52例及乳腺腺病15例组织中P16的表达情况,分析其与临床病理参数的关系。结果P16在乳腺癌中的阳性表达率为44.2%(23/52),乳腺腺病为73.3%(11/15),其差异有统计学意义(P<0.05),并且其阳性表达率与肿瘤分化程度和淋巴结转移密切相关(P<0.05)。结论P16基因的异常表达,可能导致肿瘤细胞增殖活性增加,促进肿瘤的发生;而且可能是导致乳腺癌淋巴结转移的重要原因。Objective To investigate the relationship between the expression of P16 in the breast cancer and adenosis and clinicopathologic features. Methods The expression of P16 was detected in 52 patients with breast cancer, 15 patients with adenosis by the immunohistochemical staining. Results The frequency of P16 staining in breast cancer was 44.2%（23/52）,being significantly higher than that of in adenosis73.3%（ 11/15 ）（P〈0.05 ）. Furthermore,the positive expression of P16 was associated with high grading and lymphytic metastasis（P〈0.05 ）. Conclusion The abnormal expression of P16 may associate with the occur of tumor,proliferation and lymphytic metastasis.

关 键 词：P16 乳腺癌 乳腺腺病 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]