吉非替尼治疗62例中晚期非小细胞肺癌疗效分析  

Sixty-two Patients with Advanced Non-small Cell Lung Cancer were Treated with Gifitinib

作　　者：陈东升[1] 郁小凤[1] 

机构地区：[1]广东医学院附属湛江中心医院肿瘤科,524037

出　　处：《中华全科医学》2010年第4期433-433,522,共2页Chinese Journal of General Practice

摘　　要：目的观察应用吉非替尼治疗对化疗耐药的中晚期非小细胞肺癌的疗效和不良反应,以及对生活质量的影响。方法62例既往化疗失败的Ⅲb～Ⅳ期非小细胞肺癌患者,口服吉非替尼250mg/d,服药至病情进展或出现不能耐受的不良反应,观察吉非替尼的疗效和不良反应,以及患者的生活质量。结果62例患者均可评价疗效,其中CR2例,PR16例,SD38例,PD6例,总有效率(RR)为29.0%(18/62),临床受益率90.3%(56/62),ECOG评分稳定及改善为71.0%(44/62)。最常见的不良反应为皮疹(27.4%),多伴发皮肤干燥和瘙痒。结论吉非替尼对化疗耐药的中晚期非小细胞肺癌疗效确切,改善生活质量且不良反应轻,耐受性好。Objective To investigate the antitumor effect,adverse reactions,and quality of life of gefitinib in treating advanced non-small cell lung cancer.Methods Sixty-two patients with Ⅲb to Ⅳ NSCLC who had previously been treated with 2-7 cycles of platinum-based chemotherapy were enrolled into the study,the regimen was oral intake of gefitinib 250 mg once daily until the disease progression or intolerable toxic reaction occurred.The efficacy,adverse reactions of gefitinib and quality of life of patients were observed.Results All 62 patients were evaluable for therapeutic effect.Among the 62 patients,2 cases got complete response（CR）,16 partial response（PR）,38 stable disease（SD） and 6 progression（PD）.The total response rate was 29.0%（18/62）and the disease control rate was 90.3%（56/62）,and ECOG score was improved or remained stable in 71.0%（44/62）.The major adverse reactions of gefitinib included rash,itching and diarrhea.Conclusion Gefitinib was effective and safe for patients with advanced non-small cell lung cancer who failed prior chemotherapy and radiotherapy.The toxicities of gefitinib were tolerable.

关 键 词：吉非替尼 非小细胞肺癌 表皮生长因子受体 

分 类 号：R734.2[医药卫生—肿瘤] R730.53[医药卫生—临床医学]