NF-κB及IL-1ra在胃癌中的表达及其意义  

Expression of NF-κB and IL-1ra in Gastric Cancer and Its Clinical Significance

作　　者：王康玮[1,2] 曹清华[1] 林原[1] 肖萍[1] 车丽洪[1] 罗灿峤[1] 薛玲[1] 

机构地区：[1]中山大学附属第一医院病理科,广东广州510080 [2]广州市南沙中心医院病理科,广东广州511457

出　　处：《中山大学学报（医学科学版）》2010年第1期95-99,共5页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：广东省自然科学基金(9151008901000117)

摘　　要：【目的】探讨NF-κB及IL-1ra在胃癌中的表达及其意义。【方法】通过组织芯片,采用免疫组织化学方法(LSAB法)检测核因子-κB(NF-κB)和抗炎因子白细胞介素-1受体拮抗剂(IL-1ra)在359例胃癌组织中的表达情况。【结果】NF-κB在伴发淋巴结转移、处于TNMⅢ+Ⅳ期、组织学分化较低的胃癌患者中的表达水平分别为80.2%、80.0%、79.2%;IL-1ra在原发灶癌直径≤3cm、早期癌、无淋巴结转移和处于TNMⅠ+Ⅱ期的胃癌患者中表达水平分别为61.7%、75.0%、66.4%、61.9%;NF-κB表达阴性的胃癌患者5年生存率高于阳性患者(P=0.036);伴IL-1ra阳性表达的NF-κB阴性表达患者生存率高于其它组别患者(P=0.021)。【结论】NF-κB的表达水平可以作为胃癌预后不良的指标;IL-1ra可能是延缓胃癌恶性发展的保护因素,但尚需进一步的研究证实。【Objective】 To investigate the expression of NF-κB and IL-1ra in gastric cancer,and to explore their correlation with the clinicopathological parameters and prognosis of gastric cancer （GC）.【Methods】 Expression of NF-kB and IL-1ra was detected by immunohistochemistry in tissue microarry of 359 cases of GC.【Results】 The expression rates of NF-κB in the patients with metastasis of lymph node,TNM III-IV stage,and poorly differentiated of histology were 80.2%,80.0%,and 79.2%,respectively.The expression rates of IL-1ra in the patients with tumor size ≤ 3 cm,early stage,non-metastasis of lymph node,and TNM I-II stage were 61.7%,75.0%,66.4%,and 61.9%,respectively.The 5-year survival rate of the cases with non- expressed NF-κB was statistically higher than that of the cases with expressed NF-κB（P = 0.036）.The 5-year survival rate of the patients with negative expression of NF-κB and positive expression of IL-1ra was statistically higher than the others （P = 0.021）.【Conclusions】 NF-κB is the adverse predictors of prognosis of gastric cancer.IL-1ra maybe play a protective role in early gastric cancer stage,but it is necessary to study deeply and get more evidences.

关 键 词：NF-ΚB IL-1RA 组织芯片 胃癌 

分 类 号：R735.2[医药卫生—肿瘤]