帕金森病脑深部灰质核团MR T_2值的初步研究  

Study on T_2 Value of MRI in Brain of Deep Gray Nucleus with Parkinson's Disease

作　　者：汤敏[1,2] 焦俊[1] 沈桂权[1] 魏渝清[1] 洪早云[1] 

机构地区：[1]贵阳医学院第一附属医院放射科,550004 [2]陕西省人民医院CT,MRI室,710068

出　　处：《临床放射学杂志》2010年第3期303-306,共4页Journal of Clinical Radiology

摘　　要：目的探讨脑深部灰质核团MRT2值在帕金森病(PD)中的诊断价值及意义。资料与方法选取PD患者20例和对照组10名,分别对黑质、红核、尾状核、壳核、丘脑进行MRI扫描,根据Block方程求T2值,对两组各核团T2值采用成组设计定量资料是否呈正态分布、方差是否齐性,选择t检验、近似t检验;PD患侧黑质T2值与疾病分期进行相关分析;采用随机成组设计对不同分期(1～2期、2.5～3期、4期)PD组患侧感兴趣区(ROI)T2值进行组间比较,P<0.05有统计学意义。结果(1)20例PD组患侧黑质与10名对照组黑质T2值比较有统计学意义(P<0.05),PD组黑质T2值(29.65±3.41)较对照组黑质T2值(32.45±1.78)明显减低;PD组患侧红核、尾状核、壳核及丘脑ROI与对照组ROI无明显统计学意义(P>0.05)。(2)PD组患侧黑质T2值与疾病不同分期呈负相关性(r=-0.733)。(3)不同分期(1～2期、2.5～3期、4期)PD组患侧黑质T2值有统计学意义(P<0.05),且T2值逐渐减低;壳核在2.5～3期与4期有统计学意义(P<0.05),且表现为2.5～3期T2值减低(31.74±2.80),4期壳核T2值增高(36.74±0.63);丘脑1～2期与4期T2值有统计学意义(P<0.05)。结论(1)PD组患侧黑质T2值较对照组减低,提示PD患侧黑质脑铁病理性沉积。(2)PD组患侧黑质T2值与不同分期呈负相关性,提示PD患侧黑质脑铁沉积与疾病严重程度呈负相关性。(3)不同分期(1～2期、2.5～3期、4期)PD患侧黑质T2值明显减低,反映不同分期黑质脑铁病理性沉积不同,且随疾病的严重程度而增多;PD患侧壳核T2值从减低到增加,提示壳核脑铁沉积呈增加到减低的动态过程;4期PD患侧丘脑T2值减低,提示丘脑脑铁沉积可能是PD晚期表现。Objective To study the significance of MRI T2 Values of brain deep gray nucleus in diagnosis of Parkinson＇s disease.Materials and Methods Twenty cases of the PD with clear diagnosis and the 10 normal controls were collected in our study.All the cases performed MRI scan with the same repetition time and two different echo times to obtain the T2 weighted imaging.Signal intensity of each ROI was measured and T2 value was calculated using Block equations.Results （1） T2 values of substantia nigra were significantly lower in PD patients compared with that of in the 10 controls,while,the T2 values of other deep gray nucleus had no statistically difference between the two groups.（2） In the patients with PD,T2 values of had statistical differences between each staging in the substantia nigra,between 2.5 and 4 staging in the putamen,between 0,2 and 4 staging in the thalamus.（3） There were significantly negative correlation between T2 value in substantia nigra and disease staging.Conclusion （1） T2 values can reflect signal changes and deposition of pathological iron in the substantia nigra.（2） T2 values were gradually decreased in substantia nigra in different staging.and gradually decreased in the putamen in staging of 2.5,3and 4,which indicated that brain iron deposition was a dynamic process.Iron deposition showed also increase in the Thalamus.（3） T2 values of the substantia nigra were negatively correlated with severity of PD.

关 键 词：帕金森病 磁共振成像 T2值 铁 

分 类 号：R742.5[医药卫生—神经病学与精神病学]