香椿叶水提物对小鼠炎症抑制作用  

Anti-inflammation effect and its mechanism of aqueous extract from Toona sinensis

作　　者：阮志鹏[1] 陈玉丽[1] 林丽珊[1] 

机构地区：[1]莆田学院医学院药学系,福建莆田351100

出　　处：《中国公共卫生》2010年第3期334-335,共2页Chinese Journal of Public Health

基　　金：福建省自然科学基金(C0540025)

摘　　要：目的研究香椿叶水提物抗炎作用机制。方法观察香椿叶水提物对二甲苯所致小鼠耳廓肿胀、角叉菜胶所致大鼠足肿胀、炎症组织和血清中前列腺素E2(PGE2)、一氧化氮(NO)含量的影响。结果0.5,1.5 g/kg香椿叶水提物灌胃给药能明显抑制对二甲苯所致小鼠耳廓肿胀,抑制率分别为33.85%和46.98%;对照组大鼠注射角叉菜胶2,4 h后,足跖肿胀度为(0.68±0.19),(1.12±0.10)mL,6 h时开始恢复;对角叉菜胶所致正常大鼠足肿胀,香椿叶水提物高、低剂量组注射3和2 h后与对照组比较可明显抑制;低、高剂量香椿叶水提物可降低肿胀足爪组织中NO及PG E2含量;低剂量香椿叶水提物可降低血清中NO含量。结论香椿叶水提物可能通过影响炎症介质释放和减少NO的生成而起到抑制角叉菜胶性大鼠足肿胀作用。Objective To study the anti-inflammatory effect of aqueous extract from Toona sinensis and its mechanism.Methods The contents of prostaglandin E2（PGE2） and nitric oxide（NO） in serum and tissue were detected in rats with xylene-induced ear edema and carrageenin-induced paw edema and treated with gastric gavage of aqueous extract form Toona sinensis.Results Aqueous extract from Toona sinensis showed a marked suppressive efffect on xylene-induced ear edema of rats with the inhibition rates of 33.85% and 46.98% at the doses of 0.5 and 1.5 g/kg.The Toona sinensis extract reduced the content of NO in serum at the dosage of 1.5 g/kg and the contents of NO,PGE2 in inflammatory tissue at the dosages of 0.5 and 1.5 g/kg.Conclusion Toona sinensis has a marked inhibitive effect on carrageenin-induced paw edema in rats.The effect may he related to the inhibition of inflammtatory mediators.

关 键 词：香椿 抗炎 一氧化氮 前列腺素E2 

分 类 号：R978.19[医药卫生—药品]