噻氯匹定对活化的血小板影响及其临床意义  

The effect of ticlopidine on activated platelets and its clinical significance.

作　　者：何作云[1] 于学军[1] 文芳[1] 

机构地区：[1]第三军医大学新桥医院心血管病研究室,重庆400037

出　　处：《中国心血管杂志》1998年第6期413-416,共4页Chinese Journal of Cardiovascular Medicine

摘　　要：目的:探讨噻氯匹定增强地尔硫草和5—单硝酸异山梨醇酯抗心肌缺血的疗效及其机制.方法:不稳定型心绞痛常规治疗组(CG)及合用噻氯匹定组(TG)各20例,检查其治疗前、后心肌缺血总负荷和缺血性ST段事件次数;血小板的粘附率、聚集率和血小板计数;血小板膜GP Ⅰ b、GP Ⅱ b和GP Ⅲ a.结果:用药4周时,TG中心肌缺血明显改善;血小板的粘附和聚集功能基本恢复正常,GPⅠb相对含量明显降低,血小板计数明显增加,然而后两项指标未恢复正常(P<0.05);尽管CG中心肌缺血亦有一定程度的改善,但对血小板计数、粘附和聚集功能以及CPⅠb无明显的影响.结论:噻氯匹定具有增强抗心肌缺血的作用,抑制血小板的活性是其主要的机制之一.Objective: In order to investigate therapic effect of increased antimyocardial ischemia and its mechanism with ad-ditinal ticlopidine(TG)in patients with unstable angina used diltiazem and isosorbide - 5 - mononitrate(CG) . Methods:Total ischemic burden (TIB), counts of ischemic events, adhesive rate and aggregation rate of platelet, counts of platelet, platelet membrane glycoprotein Ⅰb(GP I b). GP Ⅱ b and GP Ⅲ a were examined before and after administrated those drugs in both TG(n = 20) and CG(n = 20) . Results: Parameters of myocardial ischemia were markedly improved, adhesive rate and aggregation rate of platelet fundamentally recured, relative counts of GP I b were significantly declined, but last two marks also were abnormal(P < 0.05) . Though myocardial ischemia also improved, counts of platelet, adhesive rate and aggregation rate of platelet and relative count of GP I b diden' t greatly change in CG. Conclusion: It is suggested that ticlopidine plays a role in increased antimyocardial ischemia and inhibit actitity of activated platelet is one of its important mechanism.

关 键 词：噻氯匹定 血小板 心肌缺血 疗效 

分 类 号：R972.3[医药卫生—药品]