银杏叶提取物配合康复锻炼治疗轻度认知障碍的临床疗效观察  

Effect of the combination of Ginaton and rehabilitation exercise on mild cognitive impairment

作　　者：田晓彦[1] 高玉艳[1] 张伟兵[1] 宋荣荣[2] 张春英[2] 沈岩[1] 任艳丁[1] 

机构地区：[1]哈尔滨医科大学第四临床医学院老年病科,黑龙江哈尔滨150001 [2]哈尔滨医科大学神经内科,黑龙江哈尔滨150001

出　　处：《哈尔滨医科大学学报》2010年第1期74-76,共3页Journal of Harbin Medical University

基　　金：黑龙江省教育厅科研项目(11511153)

摘　　要：目的比较银杏叶提取物+康复锻炼与银杏叶提取物治疗轻度认知障碍(mild cognitive impairment,MCI)疗效的差别,以及探讨事件相关电位(ERPs,P300)用于轻度认知障碍治疗疗效评价。方法150例MCI患者随机分为3组,银杏叶提取物+康复锻炼组、银杏叶提取物治疗组、空白对照组,进行3个月临床试验,试验前后均进行MMSE评分与ERPs检查,统计分析。结果银杏叶提取物+康复锻炼组、银杏叶提取物治疗组、空白对照组试验前后MMSE评分、P300的潜伏期的差值与波幅的差值比较,3组之间差异有统计学意义(P<0.001)。结论治疗后两治疗组患者认知功能均有改善,且银杏叶提取物+康复锻炼明显优于单纯银杏叶提取物治疗,P300能较客观地评价MCI治疗疗效。Objective To compare the therapeutic effect on mild cognitive impairment between the Ginaton add rehabilitation exercise and the simple Ginaton,and to investigate the significance of event-related potentials at the therapeutic effect on mild cognitive impairment.Methods 150 mild cognitive impairment patients were randomly divided into 3 groups： the Ginaton add rehabilitation exercise group,the simple Ginaton group and the blank gruop.3 months clinical therapy was taken.All the patients were examined by mini-mental state examination and the latence and wave of event related potential before and after the experiments.And then compared data.Results Before and after the trial,compared the diffe-rent value of mini-mental state examination and the latence and wave of event related potential of the three groups,the therapeutic effect of Ginaton add rehabilitation exercise group was better（P0.001）.Conclusion The two treated groups are both improved,and the Ginaton add rehabilitation exercise group is better.ERPs can evaluate objectively the curative effect on the mild cognitive impairment.

关 键 词：轻度认知障碍 事件相关电位 银杏叶提取物 康复锻炼 

分 类 号：R749.16[医药卫生—神经病学与精神病学]