去卵巢对大鼠睑板腺上皮细胞超微结构的影响  

Effect on epithelial ultrastructure of meibomian gland in ovariectomized rats

作　　者：韦立顺[1] 关华[1] 杨以会[1] 李联祥[1] 张宇新[2] 

机构地区：[1]河北工程大学医学院,河北省邯郸市056002 [2]华北煤炭医学院,河北省唐山市063002

出　　处：《实用医学杂志》2010年第4期576-578,共3页The Journal of Practical Medicine

摘　　要：目的:观察去卵巢后对大鼠睑板腺腺泡上皮超微结构的影响。方法:选择72只雌性青春期SD大鼠,随机分为手术组、假手术组和正常组。分别在2、4、6、8周检测血清雌二醇浓度,并随机取24只大鼠上睑板组织做透射电镜观察。结果:手术组术后4～8周血清雌二醇的浓度显著低于正常组和假手术组(P<0.05)。手术组术后4～8周,睑板腺腺泡上皮的基底细胞、过渡细胞损伤显著。结论:去卵巢后睑板腺腺泡上皮超微结构有明显的病理学改变。Objective To observe the effect on epithelial ultrastructure of meibomian gland acinus in ovariectomy rats. Methods Seventy-two adolescent female SD rats were selected and randomly divided into operated group,sham-operated group and normal group. Serum levels of estradiol were detected by radioimmunoassay on 2 weeks,4 weeks,6weeks,8weeks,respectively,and upper meibomian tissues in randomized 24 rats were observed by electron microscopy. Results Compared with normal group and sham-operated group,serum levels of estradiol in operated group was significantly lower from 4 to 8 week respectively （P〈0.05）. The basal cells and transitional-cells of meibomian gland acinus epithelial were obviously damaged in operated groups from 4 to 8 week postoperation. Conclusion There are obvious pathologic changes in the epithelum ultrastructure of the meibomian gland acinus in ovariectomized rats.

关 键 词：卵巢切除术 大鼠 睑板腺 超微结构 睑板腺功能障碍 

分 类 号：R777[医药卫生—眼科]