食管癌高发区食管癌患者遗传易感性对生存期的影响  

Effect of hereditary susceptibility on prognosis of esophageal cancer patients in a high incidence area

作　　者：李秀敏[1] 赵志敏[1] 张渊智[2] 周福有[3] 王建坡[3] 王立东 常扶保 侯晓华[6] 

机构地区：[1]新乡医学院,453003 [2]昆明市第一人民医院,650011 [3]河南省安阳市肿瘤医院,455000 [4]不详 [5]河南省林州市中心医院,456550 [6]华中科技大学同济医学院协和医院,武汉市430022

出　　处：《实用医学杂志》2010年第4期675-678,共4页The Journal of Practical Medicine

摘　　要：目的:探讨太行山区食管癌高发区食管癌患者的恶性肿瘤遗传易感性对预后的影响。方法:回顾性调查太行山区林州市及其周边食管癌高发区的742例食管癌患者的年龄、性别、食管癌家族史、恶性肿瘤家族史、生存时间等内容,运用t检验、Kaplan-Meier法等方法比较具有恶性肿瘤家族史的食管癌患者与无恶性肿瘤家族史的患者生存时间的差异。结果:患者的平均发病年龄与遗传易感性无关;食管癌家族史阳性组的生存时间(月)明显高于阴性组(59.83±3.60vs.37.47±1.95,P=0.002),食管癌家族史阳性组和恶性肿瘤家族史阳性组中,<60岁者的生存曲线明显高于≥60岁组者(P<0.01),而阴性组则无差异。结论:食管癌家族史阳性的患者预后较好;食管癌家族史和恶性肿瘤家族史阳性的青壮年食管癌患者预后较好。食管癌患者的预后与家族史及发病年龄相关。Objective To investigate the impact of cancer hereditary susceptibility on prognosis of esophageal cancer patients in a high incidence area around Taihang mountain in China. Methods 742 cases of esophageal cancer patients in high incidence area around Linzhou,Taihang mountain area received retrospective investigation which included age,gender,family history of esophageal cancer,family history of malignant tumor,survival time et al. Student＇s t-test and Kaplan-Meier method were used to assess differences of the survival time between patients with family history of malignant tumor and patients without family history of malignant tumor. Results The average onset age of patients was unrelated to the cancer hereditary susceptibility. The survival time of positive group of esophageal cancer family history was significantly higher than that of negative group[（59.83 ± 3.60） vs. （37.47 ± 1.95）months,P = 0.002]. Within both positive family history of esophageal cancer and malignant tumor groups,survival curve of cases under 60 years old was significantly higher than that of older than 60 years old（P〈0.01）. In contrast,there was no signifcantly difference between the negative family history of esophageal cancer group and malignant tumor group. Conclusions Esophageal cancer patients with positive but not negative family history have a better prognosis. Moreover,the young and middle-aged patients within both positive family history of esophageal cancer and malignant tumor groups had a better prognosis. Family history and onset age possess prognostic relevance.

关 键 词：食管肿瘤 遗传易感性 预后 高发区 

分 类 号：R735.1[医药卫生—肿瘤]