P^(53)及P21^(ras)蛋白在甲状腺癌的表达与分化和转移的关系  

THE RELATIONSHIP BETWEEN P 53 AND P21 ras PROTEIN EXPRESSION TO DIFFERENTIATION AND METASTASIS OF THYROID CARCINOMA

作　　者：周青波[1] 王越先[1] 武彦[1] 王涛[1] 

机构地区：[1]内蒙古医学院病理解剖学教研室

出　　处：《内蒙古医学院学报》1998年第4期228-230,共3页Acta Academiae Medicinae Neimongol

摘　　要：目的：研究Ｐ５３和Ｐ２１ｒａｓ蛋白在甲状腺癌中的表达及与甲状腺癌的分化与转移的关系。方法：对已确诊的５５例甲状腺癌组织，采用ＬＳＡＢ免疫组织化学方法标记Ｐ５３、Ｐ２１ｒａｓ蛋白。结果：Ｐ５３、Ｐ２１ｒａｓ蛋白在未分化甲状腺癌的阳性表达率分别为６３６％和９０９％；在分化型甲状腺癌的阳性表达率分别为１５９１％和６８１８％；有淋巴结转移的甲状腺癌的阳性表达率分别为６３６４％和７７２７％。Ｐ５３蛋白在未分化型甲状腺癌和发生淋巴结转移的甲状腺癌组织中的阳性表达率均为６３６％，显著高于分化型和无淋巴结转移的甲状腺癌Ｐ＜００１。而Ｐ２１ｒａｓ蛋白在分化型甲状腺癌中的阳性表达率为６８１８％，明显高于其在未分化癌的表达率（Ｐ＜００１）。结论：Ｐ５３、Ｐ２１ｒａｓ蛋白的阳性表达率可作为甲状腺癌分化程度的评估指标，而Ｐ５３和Ｐ２１ｒａｓ的高阳性表达率可反映甲状腺癌发生淋巴结转移的可能性。Objective:To study the expression of P 53 and P21 ras oncoprotein in thyroid cancer and its correlation with differentiation and metastasis of thyroid cancer.Methods:P 53 and P21 ras oncoproteins were measured in 55 cases of thyroid cancer by immunohistochemistry.Results:The expression rates of P 53 and P21 ras were 63.6% and 9.09% in undifferentiated thyroid cancer,15.91% and 68.18% in differentiated thyroid cancer and 63.64% and 77.27% in thyroid cancer with lymphatic metastasis respectively.The expression rates of P 53 were 63.6% in undifferentiated cancers and those with lymphatic metastasis,much higher than these in the differentiated cancer and those without lymphatic metastasis P<0 01.Also the expression rate of P21 ras in the differentiated cancer was obviously higher than that of in the undifferentiated cancer P<0 01.Conclusion:The positive expression of P 53 and P21 ras oncoprotein can be taken as a judging index of differentiation extent in thyroid cancer.P 53 and P21 ras reflect a kind of possibility having lymphatic metastasis in thyroid cancer.

关 键 词：甲状腺癌 癌基因 细胞分化 肿瘤转移 

分 类 号：R736.1[医药卫生—肿瘤] R361.3[医药卫生—临床医学]