120例垂体生长激素腺瘤及多激素腺瘤的临床和病理学特点分析  

Analysis of clinical and pathological characteristics of GH-secreling pituitary adenomas and mixed pituitary adenomas in 120 patients

作　　者：周芬[1] 张木勋[1] 雷霆[2] 

机构地区：[1]华中科技大学同济医学院附属同济医院内分泌科,武汉430030 [2]华中科技大学同济医学院附属同济医院神经外科,武汉430030

出　　处：《中国临床神经外科杂志》2010年第2期92-94,共3页Chinese Journal of Clinical Neurosurgery

摘　　要：目的分析120例垂体生长激素（GH）腺瘤及多激素腺瘤患者的临床及病理学特征。方法回顾性分析120例免疫组化证实的垂体GH腺瘤及多激素腺瘤患者的临床资料,包括临床表现、生化改变、病理分型及侵袭性等。结果垂体腺瘤的好发年龄为20~50岁,男女发病比约为1：2,主要的临床表现为肢端肥大、头痛头晕、视力下降、视野缺损,女性患者表现有闭经、泌乳或月经紊乱。本组各种类型的垂体腺瘤的侵袭性比例：GH（＋）腺瘤为59.57%（28/47）、GH（＋）及PRL（＋）二种激素混合性瘤为35.48%（11/31）、GH（＋）和ACTH（＋）为33.33%（1/3）、GH（＋）和TSH（＋）为0（0/4）、GH（＋）和LH（＋）为33.33%（1/3）,以及GH（＋）及其它二种以上激素（＋）的多激素腺瘤34.38%（11/32）。单纯GH垂体腺瘤的侵袭性明显高于GH（＋）伴其它激素（＋）的垂体腺瘤的侵袭性（P0.05）。结论本组病例女性多于男性,单纯GH垂体腺瘤侵袭性明显高于其他类型的垂体腺瘤;病理免疫组化提示GH腺瘤除GH（＋）外,常常伴随其他激素（＋）。Objective To analyze the clinical and pathological characteristics of the GH-secreting pituitary adenomas and mixed pituitary adenomas.Method The clinical data of 120 patients with of GH-secreting pituitary adenomas or mixed pituitary adenomas,including clinical manifestations,biochemical change,pathological type,invasiveness and so on,were analyzed retrospectively.Results The GH-secreting pituitary adenomas and mixed pituitary adenomas occurred more in people aged 20～50 years than those in the others.The ratio of men to women was 1：2 in 120 patients.The main clinical manifestations included the acromegaly,headache,dizziness,visual extinction and defect of the visual field in the patients with GH-secreting pituitary adenomas and amenorrhea,lactopoiesis and menstrual disorder in women with GH-secreting pituitary adenomas.The percentage of the invasive tumors of GH（＋）,GH（＋） and PRL（＋）,GH（＋） and ACTH（＋）,GH（＋） and TSH（＋）,GH（＋） and LH（＋）,and mixed pituitary carcinomas of more than three hormones（＋） [including GH（＋）] were 59.57%,35.48%,33.33%,0%,33.33%,and 34.38% respectively.The invasive tumor percentage of the simple GH-secreting pituitary adenomas was significantly higher than that of the other tumors accompanied by GH（＋）.Conclusions The pituitary adenoma in the women is more common than that in the men.The invasive tumor percentage of the simple GH-secreting pituitary adenoma is higher than that of the other pituitary adenomas.It is suggested that besides the positive GH,there are often positive other hormones in the GH adenomas.

关 键 词：生长激素垂体腺瘤 多激素垂体腺瘤 临床表现 病理学特征 

分 类 号：R736.4[医药卫生—肿瘤]